An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Grace Collord; Patrick S. Tarpey; Natalja Kurbatova; Iñigo Martincorena; Sebastián Morán; Manuel Castro de Moura; Tibor Nagy; Graham R. Bignell; Francesco Maura; Matthew D. Young; Jorge Berna; José M. C. Tubío; Christopher E McMurran; Adam M. H. Young; Mathijs Arnoud Sanders; Imran Noorani; Stephen John Price; Colin Watts; Elke Leipnitz; Matthias Kirsch; Gabriele Schackert; Danita M. Pearson; Abel Devadass; Zvi Ram; Vincent Peter Collins; Kieren S. J. Allinson; Michael D. Jenkinson; Rasheed Zakaria; Khaja Waheeduddin Syed; Clemens Oliver Hanemann

doi:10.1038/s41598-018-31659-0

GenomicsScientific ReportsSep 4, 2018

Peer-reviewed journal article

An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Grace Collord iD, Patrick S. Tarpey iD, Natalja Kurbatova iD, Iñigo Martincorena iD, Sebastián Morán iD, Manuel Castro de Moura iD, Tibor Nagy iD, Graham R. Bignell, Francesco Maura iD, Matthew D. Young iD, Jorge Berna, José M. C. Tubío iD, Christopher E McMurran iD, Adam M. H. Young, Mathijs Arnoud Sanders iD, Imran Noorani iD, Stephen John Price iD, Colin Watts iD, Elke Leipnitz, Matthias Kirsch iD, Gabriele Schackert iD, Danita M. Pearson, Abel Devadass iD, Zvi Ram iD, Vincent Peter Collins iD, , Ultan McDermott iD

Abstract

Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of two distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Our analyses discern two biologically distinct variants of anaplastic meningioma with potential prognostic and therapeutic significance.

PDF DOI