REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?
Ajay Kumar VermaiD, Sergio Francisco Acosta Lenis, Joshua E. AmaniD, David Escobar SanabriaiD, Jing WangiD, Amy Pearson, Meghan E. HilliD, Rémi PatriatiD, Lauren E. SchrockiD, Scott E. CooperiD, Michael C. ParkiD, Noam HareliD, Michael J. HowelliD, Colum D. MacKinnoniD, Jerrold L. VitekiD, Luke A. JohnsoniD
Abstract
To elucidate the role of the basal ganglia during REM sleep movements in Parkinsons disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.
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