Time-dependent roles of adolescent- and adult-born dentate granule neurons in spatial learning

Núria Masachs; Vanessa Charrier; Fanny Farrugia; Valérie Lemaire; Wilfrid Mazier; Nicolas Blin; Sophie Tronel; Marie‐Françoise Montaron; Shaoyu Ge; Daniela Cota; Véronique Deroche‐Gamonet; Cyril Herry; Djoher Nora Abrous

doi:10.1101/2020.05.08.084467

NeurosciencebioRxivMay 8, 2020

Preprint

Time-dependent roles of adolescent- and adult-born dentate granule neurons in spatial learning

Núria Masachs iD, Vanessa Charrier iD, Fanny Farrugia, Valérie Lemaire, Wilfrid Mazier iD, Nicolas Blin iD, Sophie Tronel iD, Marie‐Françoise Montaron, Shaoyu Ge iD, Daniela Cota iD, Véronique Deroche‐Gamonet iD, Cyril Herry iD, Djoher Nora Abrous iD

Abstract

The dentate gyrus presents the peculiarity to be formed after birth in rodents. Adolescence is a very sensitive period during which cognitive competences are programmed. We investigated and compared the role of dentate neurons born during adolescence or generated during adulthood. We demonstrated that the ontogenetic stage of dentate neurons in relation to when they are generated dictates their participation in memory processes.

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