genome assembly

This study shows that using a conspecific reference genome improves variant detection and genetic diversity estimates compared to heterospecific references in gray foxes.

The paper assembles the diploid genome of Mexican lime, revealing high heterozygosity and structural variants between thorned and thornless lineages.

REWRITE enables scar-minimized rewriting of native human loci exceeding 100 kb in hPSCs, demonstrated through synthetic refactoring of the class-I HLA region.

The paper presents the first chromosome-level genome assembly of the Brazilian merganser, revealing genomic features and population history insights.

The paper assembles and annotates the first chromosome-level nuclear reference genome of the grey reef shark using long-read sequencing, providing a resource for evolutionary and conservation studies.

The paper presents chromosome-level genome assemblies for five Tephritid species using long-read sequencing, short-read polishing, and Hi-C scaffolding.

This study combines rare variant burden scores and common variant polygenic risk scores to improve genetic risk prediction for schizophrenia, hypertrophic cardiomyopathy, and major depressive disorder.

This paper develops a Cas12a-based toolkit for efficient genomic editing and CRISPRi in Group B Streptococcus, enabling targeted gene modifications and inducible gene silencing with minimal off-target effects.

This study tests the effects of nucleoside analogues on fission yeast with DNA replication checkpoint mutations, revealing sensitivity patterns and potential clinical implications.

The paper presents a gap-free donkey genome assembly and identifies novel structural variants in functional genes.

This study assesses the genetic diversity and population structure of the bowmouth guitarfish in the Northwest Indian Ocean using mitochondrial and SNP data, revealing genetic differentiation and a cline in variation.

This paper estimates direct and maternal genetic effects on piglet birth weight and its variability, finding maternal effects are crucial while direct effects are negligible.

The paper introduces Hy-BLUP, a Bayesian prediction method for handling incomplete pedigree, genomic, and phenotypic data in genome-enabled prediction.

This study presents a high-quality chromosome-level genome assembly of Sinibrama wui and identifies expanded gene families related to lipid metabolism and nervous system.

This paper introduces ultra-high field electroporation to improve DNA transformation and genome editing in non-tuberculous mycobacteria, achieving significant efficiency gains in multiple species.

This study reclassifies 193 genomes as Vibrio paracholerae using genomic analysis and identifies its virulence factors and antibiotic resistance genes.

The paper shows that island isolation and genetic drift rapidly drive speciation in macaques, leading to genomic divergence, loss of diversity, and adaptive mutations.

The paper presents an improved chromosome-level genome assembly of the whale shark, revealing a chromocline effect in substitution rates across chromosomes.

This paper establishes an antimetabolite-based transformation system for Phanerochaete chrysosporium, enabling efficient genetic manipulation and heterologous gene expression.

The paper assembles and annotates the first whole genome of the ball python (Python regius), providing a high-quality resource for studying snake-specific traits and physiological adaptations.

The paper introduces a floral injection method to improve Agrobacterium-mediated transformation in Mimulus guttatus, enabling transformation of both coastal perennial and inland annual ecotypes.

This study analyzes the genetic stability and resilience of Baltic diatom populations over 8000 years, showing accelerated genetic change linked to historical human activity.

This paper generates a high-quality genome assembly for Zancudomyces culisetae using PacBio-HiFi sequencing and evaluates sequencing technologies for fungal genome assembly.

This study improves genomic prediction of stalk lodging resistance in maize by integrating multi-environment data, showing that multi-environment models significantly enhance prediction accuracy for most traits.

The paper presents a haplotype-resolved genome assembly of Puccinia hordei, revealing structural plasticity, copy number variation, and evolutionary dynamics in a barley fungal pathogen.

The paper presents the first chromosome-level genome assembly of the Siberian flying squirrel, providing insights into its evolutionary relationships and conservation genetics.

The paper presents chromosome-level genome assemblies for two wild cherry species, revealing structural variations and insights into their evolutionary relationships.

The paper develops a genetic tool for Bactrocera zonata by creating a chromosome-level genome and CRISPR/Cas9-induced white-eye mutants to aid in Genetic Sexing Strain development.

This study identifies KDM4A as a centrosome-associated protein whose demethylase activity maintains centrosome integrity and genomic stability.

The paper presents the genome of the Glacier lanternfish, revealing loss of adaptive immune system genes and providing insights into immune system evolution in lanternfishes.