Neurotransmitter Receptor Influence on Behavior

This study shows that inhibiting the ventral pallidum during alcohol cues reduces Pavlovian alcohol-seeking behavior in rats.

The paper identifies cue-specific neurotransmitter changes in the medial prefrontal cortex of rats during relapse-promoting and relapse-suppressing cues for cocaine or alcohol self-administration.

The paper investigates how rewarding and aversive stimuli affect DRD1 and DRD2 dopamine receptor-expressing neurons in the central amygdala, showing differential activation patterns.

This study measures dopamine release in striosomal compartments of mice during classical conditioning, showing differential release in response to rewarding and aversive stimuli.

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

The paper compares grouping by biological sex versus individual attributes to identify behavioral diversity in psychostimulant activity, finding that individual clustering reveals greater differences than sex-based grouping.

This study uses chemogenetic techniques to show that the ventral pallidum-nucleus accumbens shell pathway modulates sucrose consumption without affecting food-seeking motivation in female rats.

This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The study validates the MISSING model to explain inconsistencies in sex differences in methamphetamine self-administration by analyzing behavioral clusters in male and female rats.

This study shows that optogenetic stimulation of VTA to NAcbS projections impairs reversal learning and increases exploitation bias in rats during probabilistic reversal learning.

This study shows that predator odor stress increases male rats' sensitivity to alcohol via GABAA receptor changes in the prelimbic cortex, but not in females.

This study investigates how valence encoding transforms through the striatopallidal circuit by comparing odor identity and reward contingency encoding in the anteromedial olfactory tubercle and ventral pallidum.

The paper identifies three temporally sequenced clusters of NAc neuron activity in mice during reward seeking and shows that D1 and D2 neuron activity at specific times predicts and influences lever-pressing behavior.

The paper identifies nucleus accumbens inhibitory interneurons as a key site where mu opioid receptor expression promotes social behavior, distinct from its role in exogenous opioid sensitivity.

This study shows that dopamine D1 receptor activation in the anterior insula increases anxiety-related behaviors and disrupts neural coding of exposed versus protected spaces.

This study shows that prior cocaine use changes neural ensemble representations in the orbitofrontal cortex, affecting decision-making in rats.

The paper compares grouping subjects by biological sex versus behavioral clustering to identify distinct groups with specific dopamine activity patterns in rats.

This study investigates how obesity affects working memory gating and finds that dopaminergic gene variants and amino acid ratios influence cognitive flexibility in high-BMI individuals.

This study identifies a genetic variant in DNAJC13 that influences neural activation in the reward system in response to conditioned stimuli using GWAS and fMRI.

This study shows that sequence termination cues, via dopamine signaling, drive habitual behavior by enhancing automaticity and reducing behavioral flexibility.

The paper shows that pre-existing visual responses in dopamine terminals predict individual learning trajectories in mice during a visual task.

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

This study shows that dopamine release patterns in the dorsal striatum differ between medial and lateral regions during learning, challenging classic reinforcement learning models.

The paper identifies a striosomal ACB projection to the Esr1+ LHA-LHb pathway that drives compulsive seeking behaviors through aversive signaling.

The paper identifies distinct transcriptional changes in dopamine neurons during cocaine taking and craving using a mouse model and nuclear RNA-sequencing.

The paper demonstrates that activation of mGlu2/3 receptors in the basolateral amygdala inhibits reward seeking triggered by discriminative stimuli in rats.

This study investigates structural brain network changes in methamphetamine users during long-term abstinence and links them to craving mechanisms using network control theory and multimodal analyses.

This study identifies a novel epigenetic mechanism by which chronic cocaine exposure alters gene expression in nucleus accumbens neurons through H2A.Z depletion and chromatin changes.