Alfred Jay Robison

The paper shows that repetitive neuronal activation induces nuclear reprogramming, leading to cellular maturation state changes with behavioral effects similar to ECT.

The paper investigates the distinct behavioral and electrophysiological roles of oxytocin neurons in the anterior and posterior paraventricular nucleus using genetic and pharmacological manipulations in mice.

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

The paper shows that astrocyte calcium signals and the protein hevin mediate cocaine-induced reward and synaptic plasticity in the nucleus accumbens.

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

This study shows that FosB/ΔFosB in mast cells regulates gene expression to reduce allergic inflammation in male mice by enhancing DUSP4 expression.

This study shows that repeated social defeat stress in male prairie voles leads to depression-like behaviors including reduced sociability, anhedonia, and spatial memory impairment.

This study shows that KDM2B dysfunction leads to neural stem cell senescence and ASD/ID-like behaviors in mice, linking 12q24.31 microdeletions to neurodevelopmental disorders.

This study shows that loss of ASH1L in developing mouse brains leads to autistic-like behaviors and cognitive impairments, establishing a causal link between ASH1L mutations and ASD/ID.

The paper describes the generation and validation of a floxed FosB mouse line to enable spatial and temporal control of FosB gene silencing.