Neurotransmitter Receptor Influence on Behavior

The study replicates a previous finding that reward effects on cognitive control depend on dopamine synthesis capacity but fails to find a correlation in a larger sample using a different radiotracer.

This study examines how repeated social stress affects reward behavior and prefrontal cortical activity in mice, showing that neural responses diverge over time between resilient and susceptible animals.

This study investigates how dopamine affects two types of motivation in Parkinson's disease patients, finding that dopamine enhances contingent reward motivation but reduces reward-driven vigour.

This study shows that central amygdala mineralocorticoid receptors influence alcohol self-administration in rats, with MR antagonists reducing alcohol consumption.

This study shows that repeated exposure to the predator odor TMT increases alcohol self-administration and alters amygdala response to alcohol in rats, suggesting a link between PTSD-like stress and AUD.

This study examines how different photoperiods affect gene expression and monoamine levels in the dopamine and serotonin systems across mouse development.

This study shows that knocking down mu and delta opioid receptors in dopamine receptor D1-expressing neurons does not impair reward sensitivity or related behaviors.

This study investigates the role of Gadd45b in dopamine-dependent transcription and cocaine reward, showing its necessity for cocaine-induced behavioral and epigenetic changes.

This study investigates how GluN2B antagonism affects extinction consolidation of methamphetamine-seeking behavior in adolescent vs. adult rats, finding no effect on extinction but sex differences in relapse.

This study investigates how acute fasting affects excitatory and inhibitory synapses onto VTA dopamine neurons in male and female mice, finding sex-specific changes in synaptic transmission.

This study compares how cocaine, heroin, and sucrose self-administration affect perineuronal nets in different regions of the rat prefrontal cortex during early and protracted withdrawal.

The paper uses retrograde labeling to show that D1 and D2 receptor-expressing neurons in the mouse prefrontal cortex are topographically organized and project to distinct subcortical regions.

The paper shows that chemogenetic activation of mesoaccumbal GABA projections selectively reduces responding to incentive cues with decreased reward value, unlike global VTA GABA activation.

This study investigates the role of the lateral hypothalamus and orexinergic signaling in the paraventricular thalamus in attributing incentive salience to reward cues using Pavlovian conditioned approach behavior in rats.

This study shows that amphetamine alters utility encoding and neural dynamics in rat anterior cingulate cortex, with low doses increasing stability and task engagement while high doses disrupt reward signaling and task performance.

This study shows that ropinirole, a dopamine agonist, impairs proactive inhibition in healthy adults, suggesting a mechanism for impulse control disorders in Parkinson's patients.

This study shows that intermittent fentanyl self-administration in rats leads to addiction-like behaviors that are reversed by an orexin-1 receptor antagonist.

This study shows that tonically active neurons in monkey dorsal striatum signal reward and no-reward feedback during trial-and-error search behavior, but not during repeat trials.

This study identifies RPE signals in the ventral pallidum that predict task engagement and influence reward-seeking behavior in rats.

This study shows that cocaine memory reactivation reduces PV intensity and alters electrophysiological properties of PV FSIs in the rat medial prefrontal cortex.

This study shows that direct projections from the basolateral amygdala to the nucleus accumbens core are required for cue-controlled cocaine seeking behavior.

This study examines how protein restriction during adolescence or adulthood affects dopamine release in specific brain regions in rats, showing age-dependent differences in neural responses.

This study investigates the role of central norepinephrine in novelty-induced behaviors, finding that NE signaling is essential for both neophilic and neophobic responses.

The paper identifies conserved gene expression patterns between mouse cocaine self-administration and human cocaine use disorder in meso-limbic circuits.

This study investigates how adolescent intermittent ethanol exposure affects dopamine transmission and KOR function in rats, showing sex- and timing-dependent differences.

This study investigates sex differences and the effects of gonadal hormones and amphetamine on risk-based decision making in rats using a probabilistic discounting task.

This study shows that D-amphetamine reduces addiction-like behaviors and DAT sensitization in rats during intermittent cocaine self-administration.

The paper identifies mesolimbic dopamine signatures associated with different forms of alcohol-seeking relapse using photometry and dissimilarity matrices.

This study compares two cocaine self-administration procedures in rats, finding that intermittent rapid infusions increase incentive motivation and cocaine-induced gene regulation in corticostriatal regions compared to slower infusions.

This paper introduces a novel mouse self-administration procedure that improves volitional drug intake and eliminates sex bias in inclusion criteria.