Neurotransmitter Receptor Influence on Behavior

The paper introduces OpAL*, a model that demonstrates the normative advantages of dopamine and striatal opponency in learning and choice, particularly in sparse reward environments.

This study investigates the effects of brain-specific noradrenergic depletion on behavior and gene expression, finding anxiolytic effects and altered gene regulation in vulnerable brain regions.

This study shows that a ketogenic diet prevents anxiety-like behavior in male mice during sucrose withdrawal but not in females.

This study shows that serotonin release from the dorsal raphe nuclei to the orbitofrontal cortex enhances reversal learning by increasing neuronal excitability and synaptic plasticity.

This study identifies RXR as a key regulator of drug reward sensitivity in the nucleus accumbens through transcriptional control of neuronal excitability in mice.

The paper investigates how dopamine systems in the basal ganglia process reward prediction based on working memory versus random rewards in rats and mice.

This paper identifies a novel hypothalamic-midbrain circuit that supports model-based learning and shows its alteration in methamphetamine use.

The paper uses CRISPR tools to mimic cocaine-induced bidirectional regulation of Nab2 and Egr3 in specific NAc MSN subtypes.

The paper shows that larger reward expectations in mice are associated with slower dopamine rise and larger dopamine dip in the ventral striatum during task performance.

The paper investigates the role of the BLA-vHC circuit in alcohol drinking behaviors using chemogenetics and finds that inhibiting this pathway reduces appetitive drinking but not consummatory behaviors.

The paper identifies a novel stress-sensitive CRH GABA projection from the basolateral amygdala to the nucleus accumbens that contributes to reward behavior disruption following early-life adversity.

This study shows female C57BL/6J mice are more resistant to footshock punishment when self-administering ethanol compared to males.

This study shows that 5-HT1A and 5-HT1B receptor blockade separately affects motivation by altering sensitivity to cost and reward in monkeys.

This study shows that repeated footshock stress increases cocaine self-administration in both male and female rats, with CB1R signaling playing a role in this effect across sexes.

This study shows that striatal enkephalin is not required for cocaine reward acquisition but is necessary for maintaining the learned association during extinction.

The paper inhibits norepinephrine signaling during a sensitive period in mice, revealing long-term effects on emotional behaviors and LC-NE circuitry in adulthood.

This study investigates how neuro-immune signaling and choline transporter modifications contribute to addiction vulnerability in sign-tracking rats.

This study shows that serotonin in the dorsal raphe nucleus and insular 5-HT2C receptors modulate social responses to stressed rats, with effects observed in both males and females.

This paper extends homeostatic regulation into a reinforcement learning framework to model sodium-seeking behavior and dopamine signaling in rats.

This study identifies ANKK1's role in striatal DR2-expressing neurons, linking it to reward, metabolism, and behaviors associated with the A1 allele of TaqIA.

The paper shows that dopaminergic signals for reward and performance shift during courtship in songbirds, with signals routed through distinct pathways based on social context.

This study uses dopamine sensors and machine learning to analyze how dopamine dynamics in the dorsal and ventral striatum of mice correlate with behavioral patterns during exploratory behavior.

This study identifies six topographically and functionally distinct regions in the mouse central nucleus of the amygdala (CeA) innervated by different dopaminergic pathways.

This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.

This study examines sex-specific changes in motivated behavior and mesoaccumbal dopamine subcircuit plasticity during protracted morphine withdrawal in mice, finding male-specific reductions in non-drug reward motivation linked to lateral DA subcircuit alterations.

This paper computationally models neuromodulator circuits to show that multiple stable architectures can produce similar network activity, demonstrating degeneracy in dopamine and serotonin systems.

This study investigates the role of infralimbic cortex projections to the nucleus accumbens shell and amygdala in cocaine extinction learning using optogenetic inhibition in rats.

This study shows that mesolimbic dopamine adjusts the rate of learning from action in mice, supporting a model where dopamine signals set an adaptive learning rate rather than serving as an error signal.

This study shows that activating presynaptic Gq-coupled receptors causes biphasic DAT trafficking, affecting dopamine clearance and motor function.