Topic · Cancer Research · Biochemistry, Genetics and Molecular Biology
MicroRNA in disease regulation
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
308 papers
- Systems BiologyFEBS LettersPeer-reviewed
Subtle alteration in microRNA dynamics accounts for differential nature of cellular proliferation
Dola Sengupta, Vinodhini Govindaraj, Sandip Kar
The paper presents a mathematical model of the Myc/E2F/mir-17-92 network to explain how differential cellular proliferation can be influenced by microRNA dynamics in a cell-type specific manner.
14 citations - Molecular BiologyRNA BiologyPeer-reviewed
miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family
Cody J. Wehrkamp, Sathish Kumar Natarajan, Ashley M. Mohr…·Justin L. Mott
The paper identifies miR-106b-regulated genes in cholangiocarcinoma cells, revealing repression of KLF family members and their potential role in tumor biology.
9 citations - GenomicsGenome ResearchPeer-reviewed
Towards the human cellular microRNAome
Matthew N. McCall, Min‐Sik Kim, Mohammed Adil…·Marc K. Halushka
The paper establishes the landscape of human cell-specific microRNA expression using small RNA-seq data from diverse cell types and tissues, identifying novel microRNA loci and patterns correlated with super-enhancer activity.
156 citations - GenomicsBMC GenomicsPeer-reviewed
A miRNA catalogue and ncRNA annotation of theshort-living fish Nothobranchius furzeri
Mario Baumgart, Emanuel Barth, Aurora Savino…·Alessandro Cellerino
The paper presents a comprehensive miRNA and ncRNA catalogue for the short-lived fish Nothobranchius furzeri and compares it to other fish species.
26 citations - Molecular BiologyRNAPeer-reviewed
Microprocessor dynamics shows co- and post-transcriptional processingof pri-miRNAs
Annita Louloupi, Evgenia Ntini, Julia Liz, Ulf Andersson Ørom
The paper develops a method to study pri-miRNA processing kinetics in vivo and shows co- and post-transcriptional processing occurs with varying speeds.
19 citations - BioinformaticsNucleic Acids ResearchPeer-reviewed
The presence or absence alone of miRNA isoforms (isomiRs) successfully discriminate amongst the 32 TCGA cancer types
Aristeidis G. Telonis, Rogan G. Magee, Phillipe Loher…·Isidore Rigoutsos
The paper shows that binary isomiR profiles can accurately classify 32 TCGA cancer types with high sensitivity and low false discovery rate.
224 citationstop 1% - GenomicsJournal of Biological ChemistryPeer-reviewed
Functional transcriptomics in diverse intestinal epithelial cell types reveals robust gut microbial sensitivity of microRNAs in intestinal stem cells
Bailey C. E. Peck, Amanda T. Mah, Wendy A. Pitman…·Praveen Sethupathy
The paper shows microbiota regulate miRNA expression in intestinal stem cells more than other cell types, with miR-375 suppression linked to increased stem cell proliferation.
133 citationstop 3%