Aurora Savino

This study shows LSD induces adaptive stress transcriptional programs in the prefrontal cortex of mice, aligning with hormetic adaptation rather than chronic stress.

CRISPR-VUS identifies rare variants linked to gene dependency in cancer cell lines, prioritizing potential drivers and therapeutic targets through functional validation.

This study shows that LSD induces gene expression patterns opposing aging and neurodegeneration in the brain, suggesting potential therapeutic effects through transcriptional reversal.

The paper provides a dataset and R package to benchmark CRISPR-Cas9 screening pipelines using HT-29 cells and a commercial guide RNA library.

The paper introduces contrast subgraphs to compare gene and protein networks from different conditions or techniques, highlighting altered connectivity modules.

This study shows that LSD increases signalling entropy in rats' prefrontal cortex by rewiring gene co-expression networks, suggesting a link between molecular changes and brain entropy.

This study uses network analysis on breast cancer gene expression data to identify molecular features and potential drug targets, particularly in basal-like breast cancer.

The paper presents a comprehensive miRNA and ncRNA catalogue for the short-lived fish Nothobranchius furzeri and compares it to other fish species.