MicroRNA in disease regulation

This study shows miR-7975 promotes endothelial cell proliferation and migration by directly regulating MTDH, suggesting its role in early atherosclerosis.

This study identifies miRNAs as biomarkers for CKD and its cardiovascular outcomes in non-dialysis patients, showing their association with disease progression and mortality.

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

The study identifies miR-106a-3p as a regulator of adult stem/progenitor cell fate through transcriptional control in 3D cultures.

The paper introduces Scan, a framework that infers sample-specific miRNA regulation from bulk and single-cell RNA-sequencing data using multiple network inference methods.

This study examines longitudinal associations between circulating microRNAs and weight changes over two years in the Diabetes Prevention Program.

The paper identifies miR-QTLs in older adult brains and links four miRNAs to multiple neuropsychiatric and neurodegenerative diseases through integration with GWAS results.

This study identifies miR-153-3p as a regulator of neuronal genes and shows its association with Alzheimer's disease risk and pathogenesis.

The paper introduces Mimosa, a Transformer-based model for miRNA target prediction that incorporates non-canonical base-pairing patterns, achieving better performance than traditional methods.

CEDS enhances the anticancer effects of miR-26a-5p and miR-126-5p in RAW 264.7 cells by increasing miRNA expression and suppressing key signaling pathways.

CEDS modulates miRNA and DNA motif interactions, altering protein signaling pathways in RAW 264.7 cells through sequence-specific effects.

This study identifies miRNA-21-5p and miRNA-125-5p as upregulated in gastric cancer, serving as diagnostic and prognostic biomarkers through integrated data analysis and validation.

This study shows that miRNA mimic pairs synergistically reduce target gene expression in oral cancer cells, impairing metabolism and reducing proliferation, but not in normal cells.

This study identifies miR-100 and miR-125b as regulators of 3D growth and invasiveness in cancer cells, showing they can be transferred extracellularly to silence target genes in recipient cells.

The paper performs small RNA sequencing in Pristionchus pacificus to study miR-100 and the let-7-complex, finding novel miRNAs, developmental expression patterns, and alternative locus arrangements.

Gra-CRC-miRTar is a pre-trained graph neural network framework for identifying miRNA targets in colorectal cancer, achieving better performance than existing methods and revealing functional interactions.

The paper identifies miR-4787-3p as an essential miRNA for breast tumor-initiating cell growth using CRISPR screens and validates its role as a potential therapeutic target and prognostic biomarker.

The paper introduces miRAIDD, a database of human miRNA-disease causal associations generated using large language models, and quantifies miRNA pleiotropy and its biological characteristics.

PRIMITI predicts miRNA-target mRNA interactions using machine learning with CLIP-seq and expression data, achieving high AUC scores and outperforming existing methods.

This study identifies miR-6741-3p as a tumor suppressor in oral squamous cell carcinoma by targeting SRSF3, showing its potential as a therapeutic target.

This study identifies miR-374b as a regulator of SARS-CoV-2-induced endothelial to mesenchymal transition by targeting c-FLIP, suggesting potential therapeutic strategies for COVID-19-related vascular damage.

The paper refines miRNA target interactions using disease similarity features and Sentence-BERT, achieving high accuracy in distinguishing validated from predicted interactions.

This study identifies estradiol-induced miRNAs in endometrial cancer cells, finding miR-182 as an oncomiR that promotes proliferation and inhibits SMAD4.

This study identifies miR-144 and Hmgn2 as key regulators of chromatin condensation during erythropoiesis, showing their conserved role from fish to humans.

This study identifies miRNA-124's role in cervical cancer by regulating CD45 alternative splicing and Th cell immune function through the GSK3-PSF-CD45 pathway.

The paper introduces mime-seq 2.0, a method to sequence microRNAs from specific mouse cell types using a chimeric RNA methyltransferase tethered to Argonaute.

This study shows that miR 21 promotes carcinogenesis in hepatic cells by targeting mitochondrial genes, particularly Cox1, leading to reduced oxygen consumption and increased cellular migration.

The paper analyzes the differential expression of 10 mitochondrial microRNAs in cancerous and non-cancerous hepatic cell lines, showing an inverse relationship with their mitochondrial target genes.

The paper investigates miR 383's role in regulating mitochondrial genes and its contribution to carcinogenesis by targeting ND4L and ATP6 in the electron transport chain.

The paper investigates miR 106b's role in mitochondrial reprogramming and carcinogenesis in hepatic cells through in-silico analysis.