Leandro Castellano

This study identifies LIN28B as a post-transcriptional regulator of Wnt/{beta}-catenin signalling in myeloid leukemia cells and shows that dual targeting enhances cytotoxicity.

The paper introduces Ceudovitox, a pseudotyped-virus screening platform that identifies cell entry factors for high consequence infections, demonstrating its effectiveness in discovering novel factors like matrix metalloproteinases for CHIKV.

The paper uses single-cell RNA sequencing to show that cell-to-cell communication enhances p53 activation in response to chemotherapy, revealing a role for paracrine signaling in treatment response.

The paper identifies β-catenin-associated mRNAs in myeloid cells through RIP-seq and shows MSI2 interacts with LEF1 mRNA, regulating Wnt signaling and HSPC expansion.

The paper identifies miR-4787-3p as an essential miRNA for breast tumor-initiating cell growth using CRISPR screens and validates its role as a potential therapeutic target and prognostic biomarker.