Gut microbiota and health

This study shows pathogenic bacteria disrupt cerebral organoid structure and energy metabolism by altering glycolysis and increasing pentose phosphate pathway activity.

This paper introduces a method to reconstruct directed microbial interaction networks from static compositional data, revealing ecological dynamics and keystone taxa.

This study examines how early antibiotic and probiotic treatments affect the gut microbiome and resistome in preterm infants, finding that probiotics reduce antibiotic resistance genes and MDR pathogens but do not eliminate them.

This study shows the gut microbiome is necessary for host detoxification responses to deltamethrin, with both developmental and active microbial signaling contributing to hepatic and colonic detoxification.

This paper develops a mathematical model to understand how early-life secretory IgA and gut microbiome interactions shape immune tolerance and homeostasis.

This study shows that a wild-derived Lactiplantibacillus plantarum strain protects Drosophila from Serratia marcescens infection by acidifying specific gut regions, creating a priority effect.

This study shows dietary soy enhances T follicular helper cells and IgA in mice by promoting specific gut bacteria that drive mucosal immunity and protect against Salmonella.

This study investigates altered SIgA targeting of gut microbiota in pediatric solid organ transplant recipients and links it to dysbiosis severity.

The gut microbiota enhances translation of innate barrier defense proteins through HDAC5-mediated activation of mTORC1 signaling.

The paper creates saMBA, a large gut microbiome archive from South America, revealing high biodiversity and uniqueness, and highlights the need for more diverse microbiome research.

This study shows that inhibiting polysaccharide breakdown in Bacteroides thetaiotaomicron reduces cross-feeding and growth of Salmonella Typhimurium in mice.

This study shows that sulfoquinovose is not metabolized by mice or humans but is degraded by gut microbiota, with differences in degradation pathways between mice and humans.

The paper examines gut microbiota differences between high- and low-risk adolescents for depression, finding sex-specific links with adrenarche and Prevotella abundance.

This study examines how zinc and cobalt exposure affects Akkermansia muciniphila growth and short-chain fatty acid production, finding that high cobalt levels reduce growth while zinc increases propionate production.

The paper shows that moderate exercise improves cognitive function and neurogenesis in mice, but these benefits disappear with higher intensity or duration, and that gut microbiota changes mediate these effects.

The paper examines sex differences in gut microbiota and bile acid composition in mice, finding distinct microbial diversity and portal bile acid profiles between males and females.

This study examines gut microbiota diversity in an Indigenous Mexican community, finding age and sex-related differences and highlighting unique microbial profiles not commonly seen in Western populations.

The study compares gut microbiomes of Indians, Indo-Immigrants, Indo-Canadians, and Euro-Canadian controls to assess the impact of dietary acculturation on microbiome composition and IBD risk.

The paper investigates causal relationships between gut microbiome traits and age-related phenotypes, finding significant associations with ApoM protein levels and other plasma proteins.

This paper investigates how Parabacteroides distasonis colonization affects the microbiome, immune responses, and diabetes onset in NOD mice, finding it induces insulitis and activates specific T-cells without causing broad inflammation.

This study shows that territorial intrusions in red squirrels facilitate microbial transmission, increasing gut microbial diversity and similarity among socially associated individuals.

This paper defines human gut microbiota at subspecies resolution, identifies disease-associated subspecies, and shows that subspecies-level analysis improves CRC diagnosis compared to species-level methods.

This paper estimates absolute bacterial biomass in the gut using host-derived read normalization from metagenomic data, showing it tracks antibiotic treatment response in mice and humans.

This study uses low-pass whole metagenome sequencing to analyze gut microbiome functional capacity and diversity in an Argentine urban population, finding reduced alpha-diversity and impaired metabolic potential in the unscreened cohort.

The paper quantifies the metabolic flux of fermentation products from the gut microbiota, showing it varies with diet but not microbiota composition.

This study examines how short-term animal product restriction alters the human gut microbiome and host plasma biology in a religiously motivated dietary group.

This study shows maternal diet affects offspring microbiota and health through goblet cells, leading to long-term disease susceptibility.

This study uses multi-omics data to reveal reduced taxonomic and functional diversity in the gut microbiome of Parkinson's disease patients.

This study shows that butyrate supplementation prevents cognitive impairments and blood-brain barrier damage in mice with gut microbiome depletion caused by antibiotics.

The paper examines how environmental and maternal factors influence infant gut metabolism through microbiome and metabolome profiling in Bangladeshi mother-infant pairs.