Neuroscience and Neuropharmacology Research

This study shows that overexpression of EAAT3 in hippocampal principal neurons impairs LTD and reversal learning, suggesting EAAT3 regulates synaptic plasticity and cognitive flexibility.

This study identifies Chrdl1's role in regulating neuronal vulnerability after ischemic stroke by stabilizing GluA2 and limiting apoptosis, with region-dependent effects.

The paper develops a method to profile synaptic proteomes under physiological conditions and identifies EGFR signaling as a key activity-dependent process at synapses.

This study uses single-particle tracking to show that ARC/ARG3.1 protein shuttles between cytoplasmic clusters and the nucleus in response to synaptic activation.

This study identifies PCDH17 and PCDH10 as molecular organizers of two distinct indirect basal ganglia circuits that regulate task learning and sensorimotor habituation.

This study shows that adult mice can exhibit reversible presynaptic plasticity at thalamocortical synapses through visual deprivation and light reintroduction.

This study shows that astrocyte-expressed STAT3 maintains glutamate transporter levels and promotes ethanol consumption in male mice.

The paper investigates the molecular mechanisms of early and late long-term potentiation (LTP) by manipulating CaMKII activity and shows that L-LTP can occur without CaMKII activation.

This study shows fascin is present in dendritic spines and regulates synaptic plasticity, challenging previous assumptions about its role in neurons.

The paper identifies a core module of proteins involved in synaptic plasticity in epileptic synapses using network analysis and validates findings with patient transcriptomic data.

This study shows that NMDA receptor hypofunction in GABAergic interneurons causes pathway-specific excitatory/inhibitory imbalance in mPFC pyramidal neurons, affecting only ventral hippocampal inputs.

This study shows GluD1 is essential for maintaining GluN2B-containing NMDAR function, synaptic plasticity, and memory, with implications for neuropsychiatric disorders.

The paper investigates the structural and functional roles of dendritic spines in cortical circuits, showing they support neuronal ensembles through specific connectivity patterns and synaptic organization.

This study shows that adolescent alcohol exposure disrupts astrocyte-synaptic coupling in male rats, leading to persistent behavioral impairments that can be partially reversed by astrocyte activation.

The paper examines how tauopathy affects dendritic spine function and structure in mice, finding that spines in tau mutants are hypoactive and less tuned compared to controls.

This study shows that homeostatic synaptic plasticity increases AMPA receptor levels in motoneurons during hibernation, enhancing synaptic transmission at cool temperatures and enabling motor behavior restart after inactivity.

This study shows that mice lacking Synaptotagmin-7, which is required for synaptic facilitation, have impaired cognitive flexibility in dynamic reward tasks but not in stable ones.

The paper generates and validates an Acan-Cre mouse line that selectively labels Class-B excitatory neurons in the cerebellar nuclei for functional studies.

The paper models astrocyte electrophysiology to show that localized potassium stimuli disrupt Nernstian behavior, with responses governed by conductance ratios and synaptic input specificity.

This study shows that low-dose radiation increases cortical excitability in mice, suggesting potential therapeutic use for neuronal circuit disorders.

The paper analyzes dendritic spine nanostructure in mouse models of neuropsychiatric disorders, identifying schizophrenia and autism-related spine morphology changes and a role for Ecrg4 in spine dynamics.

This study examines neuronal and astrocytic changes in the lateral habenula during ethanol withdrawal in rats, finding reduced neuronal firing and impaired glutamate clearance.

This study examines the electrophysiological properties of rat hippocampal granule cells along the dorsoventral axis, finding increased excitability and blade-specific firing rate differences.

This study identifies C3 and CD47 as dual mechanisms refining spinal sensory-motor circuits by eliminating inappropriate synapses during development.

This study identifies HSF1's role in regulating thalamostriatal synapses and cognitive flexibility by controlling transcriptional programs and actin dynamics.

The paper identifies a novel core-rim vesicular architecture in GABAergic neurons using ultrastructural analysis, challenging traditional models of transmitter packaging.

This study identifies a cell-type-specific synaptic mechanism in the nucleus accumbens linking early Aβ accumulation to circuit dysfunction in early Alzheimer's disease.

This paper identifies a novel de novo HOMER1 variant that disrupts protein scaffolding, calcium signaling, and synaptogenesis, contributing to neurodevelopmental disorders.

This study identifies ophthalmate as a striatal neuromodulator that interacts with dopamine and selectively modulates GABA and glutamate release in motor pathways.

The paper shows developing cortical neurons achieve activity setpoints through input-selective synaptic remodeling, overcoming perturbations by selectively strengthening excitation and reducing inhibition.