Alzheimer's disease research and treatments

This study identifies viral-mediated mechanisms linking specific viruses to Alzheimer's Disease through systems bioinformatics analysis of virus-host protein interactions.

This study identifies gene coexpression rewiring between brain regions in Alzheimer's disease using differential correlation analysis of RNA-seq data from multiple brain regions.

The paper assesses neurovascular uncoupling in APOE variants, finding APOEε4/ε4 shows Type-1 uncoupling and APOEε3/ε4 shows Type-2 uncoupling in aging mice.

The paper investigates how Aβ pathology affects neural activity patterns in dorsal and ventral CA1 regions of the hippocampus in APP/PS1 mice, finding distinct disruptions in population coding between the two regions.

This study shows that high choline diets in early life improve cognitive and neuronal outcomes in a mouse model of Alzheimer's, while low choline diets have mixed adverse effects.

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

The paper identifies LOAD risk genes through systems biology and shows their impact on memory function via neuronal endosomal dysfunction in C. elegans.

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

The paper shows that a high-fat, high-carbohydrate diet causes sex-specific metabolic and inflammatory issues in 5xFAD mice, which are partially reversed by inhibiting soluble TNF in males.

This paper compares Aβ fibril structures in three mouse models of Alzheimer's disease, finding age-dependent differences in plaque morphology and polymorph maturation.

The paper identifies miR-519a-3p as a potential biomarker for preclinical stages of Alzheimer's disease by showing its early upregulation in AD cerebral samples.

This study shows that astrocytic uptake of modified Aβ3(pE)-42 disrupts the endolysosomal system, leading to inflammation and synapse loss in Alzheimer's disease.

This study shows lecanemab blocks Aβ/fibrinogen complex formation, reducing clot abnormalities and synaptotoxicity in AD models.

This study models the growth of senile plaques in Alzheimer's disease, finding that plaque growth depends on the balance between Aβ aggregate deposition and autocatalytic production.

The paper identifies rare FN1 variants that protect APOEε4 carriers from Alzheimer's disease by modulating extracellular matrix deposition and gliosis.

The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.

This study shows that inhibiting the glymphatic system worsens tau spread and memory issues in a mouse model of Alzheimer's disease.

This study shows that 5-HT4 receptor agonists reduce tau pathology and improve cognitive function in PS19 mice with tauopathy.

The paper designs a 19-residue peptide that selectively induces aggregation of 4R tau over 3R tau, revealing structural and amino acid determinants of tauopathy propagation.

This study shows that inhibiting Stearoyl-CoA Desaturase in the brain of 3xTg-AD mice improves cognitive function without affecting peripheral metabolic symptoms.

This paper develops a multiscale closed-loop model of Alzheimer's disease that links proteinopathy to electrophysiological changes, revealing causal relationships between Aβ and hp-tau depositions and neural activity alterations.

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

The paper shows that lipid metabolism changes with tauopathy progression, linking pathological tau to altered lipid production and microglial lipid droplet accumulation.

This study shows that obesity affects myelination differently in the somatosensory cortex and striatum of TgF344-AD rats, explaining the obesity paradox in AD.

This study shows that tau regulates Arc stability in neuronal dendrites through a proteasome-sensitive, ubiquitin-independent pathway, affecting AMPA receptor localization and synaptic plasticity.

This study shows that TMEM106B deletion worsens tauopathy symptoms in mice, while a coding variant provides protection against cognitive decline and neurodegeneration.

This study shows that loss of TMEM106B worsens Tau pathology and neurodegeneration in PS19 mice.

The paper develops a method to detect and characterize small tau aggregates in human samples, revealing disease-specific morphological and compositional differences.

This paper demonstrates that CAR-Ms engineered to secrete M-CSF can target and reduce amyloid plaques in a mouse model of Alzheimer's disease.