Epilepsy research and treatment

This paper reviews the role of microglial IL-1β in epilepsy, highlighting its protective function and potential therapeutic implications.

This study examines the acute effects of antiseizure drugs on background neuronal oscillations in a Dravet syndrome mouse model, finding that some drugs reduce interictal spikes and alter frequency bands while others do not.

This study uses in utero electroporation to induce mTOR pathway dysregulation in rodents, revealing early developmental abnormalities in neuronal migration and axon proliferation linked to malformations of cortical development.

This study shows sodium selenate reduces seizures, cognitive dysfunction, and sensorimotor deficits in a rat model of chronic drug-resistant temporal lobe epilepsy.

This study demonstrates that microglia have a beneficial role in reducing various types of seizures using a targeted approach.

The paper computes longitudinal phenotypes in 466 individuals with developmental and epileptic encephalopathies to improve clinical trial readiness using electronic health records.

This study characterizes SCN1A gain-of-function variants and models their impact on interneuron hyperexcitability and network instability through homeostatic plasticity in early-onset epileptic encephalopathies.

This study compares iPSC-derived neurons from patients with gain- and loss-of-function SCN2A variants, finding distinct electrophysiological and transcriptomic changes associated with different disease presentations.

This paper analyzes the clinical and genetic landscape of FIRES and RSE, finding 36% of RSE patients have genetic causes, while FIRES remains largely undiagnosed.

This study identifies atypical intrinsic neural timescales in temporal lobe epilepsy, showing reduced timescales in multiple brain regions and high accuracy in classifying patients and lateralizing seizure foci.

The paper investigates the role of prefrontal parvalbumin interneurons in attention and links their dysfunction to attentional impairments in a mouse model of absence epilepsy.

This study shows RGS14 protects hippocampal neurons from seizure-induced mitochondrial oxidative stress and pathology by modulating excitability and signaling.

This study investigates how higher-order thalamic nuclei contribute to the spread and maintenance of spike-and-wave discharges in absence seizures using GAERS models.

This paper demonstrates that interictal activity from hippocampal CA3 grafts can control limbic seizures in a biohybrid graft-host setup in vitro.

The paper identifies rare genetic variants associated with different epilepsy types, finding the most enrichment in non-acquired focal epilepsy.

The paper investigates excitability during seizure propagation in the brain, finding that single-cell excitability remains baseline while local inhibition occurs near the seizure wavefront.

This study shows that real-time optogenetic silencing of hippocampal CA2 neurons reduces seizures, interictal EEG abnormalities, and social comorbidities in mouse models of temporal lobe epilepsy.

This study investigates how early suppression of neuronal excitability in a rat model of subcortical band heterotopia affects epileptogenesis and seizure progression.

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

This paper develops a disease concept model for STXBP1-related disorders by analyzing qualitative interviews to map symptoms and their impacts across clinical domains and age groups.

The paper investigates neuronal activity patterns in a rodent model of absence seizures, finding decreased overall firing with distinct neuronal activity patterns during seizures.

This study shows that rodent hippocampal spheroids spontaneously develop epileptiform activity, resembling human and animal epilepsy models, and highlights potential risks of cell-based therapies.

This study examines how sleep stages affect neuronal firing rates during interictal epileptic activities in mesial temporal structures, finding increased firing rate modulation in deeper NREM sleep.

This study shows that slow-wave oscillations trigger seizures in a Dravet syndrome mouse model, with increased incidence in female mice.

The paper identifies genetic variants in South African children with developmental and epileptic encephalopathies and proposes a 'Think-Genetics' strategy for early genetic diagnosis in resource-limited settings.

This study shows that overexpression of two gain-of-function CYFIP2 variants in Xenopus laevis tadpoles causes spontaneous seizures, with one variant responding to valproate treatment.

This study characterizes and simulates changes in human hippocampal granule cells during epilepsy progression, identifying ion channel modifications that increase excitability.

The paper identifies a Na+ channel-dependent mechanism in hippocampal dendrites that contributes to spatial memory deficits in epilepsy and shows that targeting Nav1.3 channels can reverse these deficits.

This study shows that sensory input regulates absence seizures in Gnb1 mutant mice by modulating thalamocortical pathway activity.