Epilepsy research and treatment

This study investigates Kv1 channel downregulation in LGI1 knock-out mice, showing it occurs in somatodendritic regions and is linked to increased neuronal bursting and changes in the Kv1 interactome.

This study investigates the role of MMP9 and TGFβ signalling in MTLE-HS patients, finding increased MMP9 expression and activity, reduced ZO1, and enhanced TGFβ signalling in astrocytes.

The paper identifies specific neuronal subtypes in pediatric FCD that show significant transcriptomic alterations linked to drug-resistant epilepsy and suggests potential therapeutic targets.

This paper evaluates an artificial bridge that restores hippocampal loop function in an in vitro model of limbic seizures, reducing ictal activity and restoring connectivity.

This study investigates SCN1A mutations in excitatory neuronal networks derived from patient hiPSCs, revealing mutation-specific phenotypes that correlate with clinical outcomes and drug responses.

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

This study identifies ZFHX3 variants as a cause of childhood partial epilepsy and infantile spasms, with favorable treatment outcomes and insights into the developmental expression pattern of the gene.

This study tests N-acetylcysteine and acetyl-L-carnitine for preventing PTZ-induced seizures in zebrafish but finds no effect, while diazepam shows efficacy.

This study shows that Sema4D treatment reduces seizure susceptibility and restores benzodiazepine sensitivity in a mouse model of Status Epilepticus.

This paper optimizes a neurostimulation protocol to desynchronize pathological neuronal firing patterns during and after epileptic seizures using a computational model.

The paper investigates the relationship between sleep spindles and treatment response in epileptic encephalopathy, finding that increased spindles correlate with cognitive improvement after diazepam treatment.

The paper uses natural language processing and phenome-wide analysis to identify tachycardia as a significant comorbidity in CDKL5 deficiency disorder.

This study demonstrates that gene therapy targeting GluK2 reduces seizures in TLE models and patient-derived slices.

This study investigates the effect of DLK inhibitor GNE-3511 on epilepsy and cognitive deficits in a mouse model, finding reduced seizures, anxiety, and neuronal loss.

This study shows that in mice, female-specific left-right asymmetry in hippocampal function interacts with estrous cycle stage to influence chronic seizure patterns following kainic acid injection.

This study uses chemogenetic manipulation to show that microglia have both seizure-reducing and seizure-promoting effects in a mouse epilepsy model.

This study identifies increased chondroitin sulfate proteoglycans (CSPGs) in the hippocampus and amygdala as a cause of infection-induced epilepsy, showing their role in neuronal hyperexcitability and potential as a therapeutic target.

This study uses multisite thalamic recordings to show that seizure propagation in TLE involves thalamic regions beyond the ANT, with pulvinar involvement being more prominent in 60% of patients.

This paper introduces a novel Dravet syndrome mouse model with a Scn1a R613X nonsense mutation, showing seizures, premature death, and hyperactivity.

This study characterizes and automatically quantifies seizure-related behaviors in Xenopus laevis tadpoles using chemical induction and video analysis software.

This paper develops a high-throughput screening system for analyzing calcium waveform features in neurons to characterize anti-epileptic drugs and predict their mechanisms of action.

This study evaluates how the estrous cycle affects seizure susceptibility in Scn2aK1422E mice and finds no significant association, but notes disrupted estrous cyclicity in untreated females.

This study identifies TRPM4 as a contributor to mossy cell death in temporal lobe epilepsy following status epilepticus, affecting seizure susceptibility and memory deficits.

This study examines GABAergic system changes in KM rats during audiogenic epilepsy development, finding altered transporter expression and GABAergic activity in the hippocampus and inferior colliculi at different developmental stages.

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

This study shows that a mutation in DNM1 causes epilepsy by disrupting synaptic vesicle endocytosis, and that a drug can reverse these effects in a mouse model.

This study models human KCNT1-epilepsy in Drosophila by expressing patient mutations and shows drug responses, demonstrating the utility of Drosophila as a model for assessing treatments.

The paper identifies cell loss and subtype-specific vulnerability of interneurons in the subiculum of a mouse model for mesial temporal lobe epilepsy.

This study shows that blocking postictal hypoxia prevents SUDEP in mice by preventing seizure-induced vasoconstriction.