Epilepsy research and treatment

This paper demonstrates that a modified intrahippocampal kainic acid model in mice produces robust, frequent convulsive seizures with human-like onset patterns and high frequency oscillations.

The paper shows that interictal epileptiform discharges (IEDs) are bidirectional traveling waves that follow the same path and direction as ictal discharges, suggesting they originate outside the seizure focus.

The paper identifies acute vascular topological changes in the cortex and basolateral amygdala following experimental febrile status epilepticus in rats, which may underlie an MRI signal predictive of future epilepsy.

This study investigates the role of noradrenergic neurons in the locus coeruleus and β1-AR in cardiomyocytes in modulating SUDEP through respiratory and cardiac arrhythmias.

The paper shows that hyperventilation triggers seizures in rats by activating pH-sensitive neurons in the thalamus.

This study shows that inhibiting eEF2K reduces seizures and behavioral issues in a Dravet syndrome mouse model by enhancing GABAergic transmission.

This study disrupts synaptic output in the BNST of DBA/1 mice to reduce seizure-induced death and alter brainstem E/I balance.

This study identifies that excess interictal activity marks seizure-prone cortical areas in a genetic epilepsy model, with altered activity intensity predicting seizure burden.

This paper evaluates the pharmacoresistance of spontaneous seizures in an intra-amygdala kainate model of temporal lobe epilepsy to various antiseizure drugs, finding resistance to sodium channel inhibitors but sensitivity to GABA modulators and valproate.

This study shows that 4-phenylbutyrate (PBA) improves GABA uptake and reduces seizures in SLC6A1 mutation-related disorders by enhancing wildtype GAT-1 trafficking.

The paper analyzes GABRB3 variants in a cohort of 71 individuals to identify genotype-phenotype correlations, finding associations between variant locations and specific clinical features.

This study evaluates MEG beamformer analysis for identifying seizure onset zones in TLE patients, showing high accuracy in localizing mesial and temporolimbic foci.

The paper identifies higher levels of mobile element-associated abnormal gene transcripts in temporal lobe epilepsy patients, particularly in those with hippocampal sclerosis.

This study shows that reducing PGC-1α in PV interneurons decreases seizure-like activity in an acute epilepsy model by limiting interneuron firing intensity.

This study identifies divergent patterns of atypical cortical asymmetry and regional atrophy in temporal lobe epilepsy using MRI data from a large multi-site cohort.

This study shows that enhancing KCC2 function with CLP290 rescues PB-resistant neonatal seizures and reduces epileptogenesis in a mouse model.

This paper develops a deep learning algorithm to detect and classify epileptogenic high-frequency oscillations (eHFOs) from intracranial EEG data with high accuracy.

This study shows that loss of eaat2a in zebrafish causes seizures and reduced neuronal activity due to glutamate imbalance.

The paper identifies distinct fastigial output channels in mice and shows that stimulating neurons targeting the central lateral thalamus, but not other regions, effectively inhibits hippocampal seizures.

This study shows that increasing 4E-BP1 activity in juvenile mice with FMCD reduces neuronal dysfunction and seizures by correcting electrophysiological and structural abnormalities.

This paper introduces a novel mouse model of sustained seizure emergency with distinct pharmacological, electrographic, and pathological features compared to status epilepticus.

This study identifies a Txn1 mutation causing epilepsy and midbrain vacuolar degeneration in rats, with age-dependent neuronal and oligodendrocyte cell death and repair.

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.

The paper compares loss of consciousness mechanisms in focal impaired awareness and focal to bilateral tonic-clonic seizures using intracranial EEG data from patients.

This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.

The paper analyzes transcriptomic data from pilocarpine-induced temporal lobe epilepsy to identify predictive biomarkers and cellular mechanisms, revealing aberrant interactions between cell types and potential drug targets.

The paper analyzes ultra-rare variants in epilepsy patients to identify gene-set enrichment patterns and differential impacts in neuronal gene categories.

This study uses network control theory to analyze energy dynamics in temporal lobe epilepsy, finding increased control energy requirements and metabolic asymmetry in affected brain regions.

This study shows that somatostatin-positive interneurons with SCN8A mutations contribute to seizures by causing hyperexcitability and depolarization block.