Karen S. Wilcox

This study investigates cell-type-specific synaptic changes in the dorsolateral striatum of rats with habitual vs. goal-directed cocaine-seeking behavior and finds no significant differences in postsynaptic strength in D2 MSNs.

The paper investigates how cortical microglia respond to TMEV infection by analyzing purinergic signaling, cytokine levels, and receptor expression across brain regions.

DynamoSort automatically classifies seizure dynamotypes using machine learning, achieving performance comparable to human raters and providing probabilistic scores for seizure dynamics.

This study evaluates the efficacy of stiripentol add-on to clobazam and valproic acid in a Scn1aA1783V/WT mouse model of Dravet syndrome, showing reduced seizure frequency and therapeutic plasma concentrations.

This study uses TRAP to identify neuronal circuits involved in acute seizures during TMEV infection in mice, finding increased tdTomato expression in multiple brain regions.

This study evaluates combination therapies for Dravet Syndrome using a mouse model, finding that triple-drug regimens enhance seizure control through potential drug interactions.

This paper develops an MR-guided focused ultrasound lesioning method for small and deep brain structures in rats, achieving improved targeting accuracy.

This study develops a method to apply focused ultrasound neuromodulation in awake, head-fixed mice with temporal lobe epilepsy and evaluates its effects on seizure-like events.

The paper investigates microglial response to damage signals in a viral-induced mouse model of temporal lobe epilepsy, finding reduced P2ry12 expression and increased TNF-a during seizures and infection.

The paper evaluates the pharmacokinetics of antiseizure drugs in rodent models to assess their efficacy and duration of action.

This paper evaluates the pharmacoresistance of spontaneous seizures in an intra-amygdala kainate model of temporal lobe epilepsy to various antiseizure drugs, finding resistance to sodium channel inhibitors but sensitivity to GABA modulators and valproate.

This paper describes a moderate-throughput drug screening platform in a rat model of temporal lobe epilepsy to evaluate antiepileptogenic agents, finding no significant effect of everolimus or phenobarbital on preventing spontaneous recurrent seizures.