Multiple Sclerosis Research Studies

This study shows that microbiota modulates inflammatory responses during CNS demyelination but has little effect on remyelination in mice.

This paper reviews the psychometric properties of the PHQ-9 depression scale in people with multiple sclerosis, finding it suitable for screening but not yet validated for diagnosis or monitoring.

The paper shows that the MS risk variant rs7665090G increases astrocyte NF-κB signaling and lymphocyte recruitment, leading to larger MS lesions.

This study shows OPCs can cross-present antigen and mediate cytotoxicity in MS, suggesting they are co-opted by the immune system.

The paper identifies low-frequency coding variants contributing to multiple sclerosis risk using a large case-control study.

This study examines factors influencing fatigue and cognitive performance in MS patients, finding psychological and cognitive variables significantly predict fatigue and performance changes.

The paper identifies EBV latency III stage as a therapeutic target for MS by linking MS risk SNPs to EBV transcription factors and miRNAs.

This study shows that a BDNF mimetic targeting TrkB promotes myelin repair in a mouse model of demyelination by enhancing oligodendrocyte differentiation and remyelination.

The paper assesses serum tau and BDNF as biomarkers for MS severity, finding increased tau and decreased BDNF in MS patients, with tau correlating with disease progression.

This study identifies the sequence of grey matter atrophy progression in multiple sclerosis using longitudinal MRI data and shows its association with disability accumulation in relapsing-remitting MS.

The paper introduces a statistical technique to count distinct multiple sclerosis lesions from MRI data, showing it correlates with gold-standard counts and provides disease-related insights.

This study shows that deep grey matter volume loss predicts faster disability progression in multiple sclerosis, with specific patterns in different disease subtypes.

This study identifies a unique BOLD signal in white matter using fMRI and shows reduced signal power in multiple sclerosis patients, linking neuroinflammation to vascular dysfunction.