Protein Kinase Regulation and GTPase Signaling

The paper introduces SEDAR, a biosensor that visualizes spatio-temporal dynamics of activated Ras in Drosophila tissues during RTK signaling.

This study reveals a hierarchical organization in the kinase domain that enables regulatory plasticity through distinct functional units.

The paper investigates how phosphorylation of a PDZ-binding linear motif alters interactions with PDZ domains, showing widespread modulation of binding affinities rather than discrete on/off switches.

The paper identifies a Ral-dependent signaling cascade in C. elegans that transduces lower EGF doses to promote 2° vulval precursor cell fate.

This study investigates the role of RAP-1 in Ras-dependent cell fate decisions in C. elegans, showing it promotes fate induction and functions alongside LET-60/Ras.

This study identifies the ERK MAPK pathway as a modulator of Gq-Rho signaling in C. elegans, affecting locomotion behavior through head acetylcholine neurons.

This paper uses a computational systems pharmacology model to analyze KRAS G12C inhibitors, identifying potential strategies to improve their effectiveness and understanding resistance mechanisms.

The paper identifies and engineers phosphorylation sites on kinases to rewiring cell signaling through allosteric regulation.