Posttraumatic Stress Disorder Research

The paper performs a meta-analysis of DNA methylation data from military cohorts to identify CpG sites and regions associated with PTSD development.

This study shows that effective cognitive therapy for PTSD restores balance in brain networks involved in self-referential processing and threat detection.

The paper uses neuroimaging data to predict psychotherapy outcomes in PTSD, identifying specific resting-state networks that distinguish responders from non-responders.

The paper investigates how hippocampal volume and Cavum Septum Pellucidum (CSP) volume interact to predict PTSD symptom severity and progression in trauma survivors.

The paper examines the relationship between perceived threat bias, PTSD symptoms, and hippocampal volume in combat veterans, finding an inverse correlation between perceived threat bias and hippocampal volume.

This study identifies genetic loci associated with PTSD and its symptoms using a large veteran cohort, showing high genetic correlations between symptom sub-domains and potential drug targets.

This study investigates social cognitive impairments in PTSD using fMRI, finding hyperactivation to emotional stimuli in social brain networks, linked to symptom severity and training outcomes.

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

This study shows that observing an acute traumatic event in mice leads to long-term behavioral and physiological changes, with social relationships playing a key role in the development of PTSD-like behaviors.

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

The paper identifies sex-specific changes in monocyte proportions in males with PTSD using methylomic data, showing no such changes in females.

This study shows that pre-trauma neural circuit function predicts individual differences in threat response and vulnerability to PTSD-like behaviors in rats.

The paper identifies mir-135b-5p as a regulator of persistent stress-enhanced memory and a potential therapeutic target and biomarker for PTSD.

This study examines neural oscillations in PTSD patients during traumatic memory recall using MEG, finding distinct patterns compared to healthy controls.

This study tests CDPPB and CBD on fear extinction and anxiety in a PTSD rat model, finding CDPPB enhances extinction without increasing anxiety, while CBD reduces anxiety in susceptible rats.

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.

The paper investigates the relationship between PTSD symptoms, pulse rate variability, and ventromedial prefrontal cortex activation in combat-exposed veterans, finding associations between reduced HF-PRV and impaired vmPFC function.

This study uses a machine learning method to identify neuroimaging markers of PTSD and ELS in veterans, finding that combinatorial features improve classification accuracy.

The paper investigates neural differences between moral injury and PTSD using resting-state fMRI, finding distinct associations with brain fluctuations and functional connectivity.

The PTSD Biomarker Database compiles over 900 PTSD biomarkers from 109 studies to enable exploration and comparison of biomarker findings through interactive visualizations.

This study examines changes in brain connectivity in PTSD patients after treatment, finding reduced salience network connectivity with PCT and increased central executive network connectivity with CPT.

This study uses genetic data to show that educational attainment causally reduces PTSD risk, with economic status mediating this relationship.

The paper uses a systems biology approach to analyze how glucocorticoid receptor sensitivity and energy deficit contribute to metabolic dysfunction in PTSD.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

The paper conducts a GWAS of hippocampal subfield volumes in PTSD cases and trauma-exposed controls, identifying genetic associations and gene-environment interactions.

This study finds smaller left hippocampal CA1 volume in PTSD patients compared to trauma-exposed controls, with associations dependent on covariates.

This study finds that veterans with PTSD show no difference in DNA methylation age acceleration compared to non-PTSD veterans, but higher resilience scores are associated with increased DNAm age acceleration.

This study uses EEG to compare brain responses to auditory deviants in PTSD patients and trauma-exposed controls, finding enhanced mismatch negativity and altered theta/alpha power in PTSD.

This study identifies shared and sex-specific inflammatory pathways in PTSD through a meta-analysis of blood transcriptomes across different trauma types and biological sexes.