Developmental Biology and Gene Regulation

This study shows BMP-Smad1/9 signaling is essential for zebrafish PGC proliferation and survival but not for their fate or migration.

The paper shows that transcriptome maturation during the cell cycle enables multilineage competence in cardiopharyngeal progenitors by coupling fate decisions with cell cycle phases.

This study investigates foregut tube formation in chick embryos, revealing its narrow developmental window and biomechanical role of endoderm in elongation and heart tube formation.

The paper examines cellular changes during metamorphosis in hemichordates using single-cell RNA sequencing, revealing distinct transcriptional programs between larval and adult stages.

The paper shows NEURL proteins activate specific Notch ligands in mammals, unlike MIB1, which may explain their limited developmental role.

The paper uses microfluidics to apply controlled morphogen gradients to human embryonic stem cells, showing that absolute concentration shapes cell identity during differentiation.

The paper compares zebrafish Sox32 and Sox17 with human SOX17 to identify molecular differences in their functions during endoderm development and left-right patterning.

This paper integrates five vertebrate single-cell multi-omic atlases to reveal a conserved cellular blueprint and dual evolutionary constraints underlying early brain conservation across vertebrates.

The paper identifies conserved transcriptional regulators in monoaminergic neuron development across species using single-cell genomics and spatial transcriptomics.

This study shows that Planar Cell Polarity (PCP) signaling can polarize cells autonomously, without requiring intercellular feedback, and identifies feedback pathways that operate cell-autonomously.

The paper identifies dunnart-specific enhancers and promoters in craniofacial development, showing divergence in regulatory landscapes between marsupials and placental mammals.

The paper identifies dorsal forerunner cells that mechanically couple epiboly forces to notochord extension in zebrafish, showing their role in axis formation during gastrulation.

The paper investigates how mesenchymal tissue fields self-organize into distinct cartilage and soft tissue compartments through structural relations between cells and supracellular structures, influenced by Wnt signaling from epithelial tissue.

The paper demonstrates that axial rotation in Ciona involves leftward bending and clockwise twisting, differentially regulated by TGF-β signaling.

The paper shows that the distal-proximal GLP-1/Notch activation gradient in C. elegans germline disappears with age.

This study shows cytokinesis-induced cortical flow twists HMR-1/cadherin, breaking the first left-right symmetry in C. elegans embryos.

The paper investigates the regulatory landscape of female and male genital structures in Drosophila melanogaster, finding shared transcription factors and their expression patterns in both sexes.

This study shows that CLDN3 depletion in chick embryos increases tissue tension, leading to neural fold fusion defects in the spinal region by altering apical cytoskeletal dynamics.

The paper identifies MNX1-bound loci in motor neurons and shows MNX1 restrains pan-neuronal gene expression.

The paper identifies a molecular circuit involving C/EBP and Dlk1 that regulates fate plasticity in AT2 cells during lung development and injury.

This study identifies fgf8a as a key gene driving brain divergence in Lake Malawi cichlids through species-specific enhancer elements and functional experiments.

This study examines how temperature affects Notch signaling at multiple levels, finding that activation remains stable while transcriptional activity increases with temperature.

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

The paper identifies a Wnt signaling to Sox2 ratio that predicts neuromesodermal fate potential in zebrafish and shows Sox2's role in maintaining progenitor states.

This study identifies Osr1 as essential for bladder development by regulating epithelial-mesenchymal crosstalk and cell fate decisions through its role in signaling pathways.

This paper identifies three MAB-5 target genes that control distinct stages of posterior neuroblast migration in C. elegans, linking migration to differentiation.

The paper identifies a conserved transcriptional signature in monoaminergic neurons across Bilaterian species using single-cell transcriptomics and a novel integration method.

This study uses Small-Seq to analyze sncRNA expression in mouse and human preimplantation embryos and blastoids, revealing species-specific patterns and potential roles in development.

The paper investigates the conservation of essential germline stem cell genes across Drosophila species, finding that the function of bam is conserved in D. americana but not in D. teissieri, and that ~8% of GSC genes show absence across species.