Satoru Okuda

This study computationally designs layered tissue architectures by modulating cell-cell interfacial tension, showing how tension variations can generate structured multilayers and hierarchical organization.

This paper develops a minimally invasive optical clearing medium for live mammalian tissue imaging, enabling structural and functional imaging with minimal impact on cellular properties.

The paper examines inner ear morphogenesis across 12 vertebrate species, finding that divergent mechanical processes in tissue expansion are coordinated with developmental tempo to maintain conserved morphology.

This study identifies circumferential actomyosin bundles as drivers of endothelial cell deformations that regulate vessel diameter and prevent vascular malformations.

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

The paper demonstrates that axial rotation in Ciona involves leftward bending and clockwise twisting, differentially regulated by TGF-β signaling.

The paper shows antiparallel cell circulation arises from self-aligned polarity-dependent tension gradients in confluent tissues.

This study develops a 3D vertex model to analyze multicellular tissue mechanics, revealing strain softening and hysteresis during large deformations.

This study identifies a mechanism for epithelial stratification analogous to a phase transition, driven by foam-geometric instability and nucleation-growth processes.

The paper identifies a mechanism by which epithelial folding irreversibility is controlled through an elastoplastic transition mediated by mechanosensitive actin bracket formation.

The paper introduces a new method combining USIM and AFM to measure stiffness and biomolecular distributions in 3D living tissue, revealing mechanical heterogeneity and the role of collagens.

The paper develops a non-invasive machine learning method to estimate spatial gene expression patterns in retinal organoids using deep learning.

The paper investigates how distinct cellular dynamics regulate simultaneous morphogenetic processes in Drosophila hindgut development.