Developmental Biology and Gene Regulation

The paper identifies a tripartite neural plate border in ascidian embryos, suggesting it was present in the last common ancestor of vertebrates and tunicates.

The paper uses single-cell lineage tracing and multiomics profiling to map human neuromesoderm differentiation, revealing TBX6's role in posterior mesoderm fate diversification.

The paper identifies Gata.a, Tbx21, and Klf6/7 as cooperative regulators of zygotic genome activation in ascidian embryos, controlling ~80% of zygotically activated genes.

The paper generates positional gene expression atlases for regenerative axolotl and non-regenerative mouse limbs, revealing conserved and species-specific connective tissue signatures.

The paper develops a high-throughput system to study segmentation clock phase responses in hiPSC-derived somitoids using image-based screening and mathematical modeling.

The paper investigates gene family evolution across Pancrustacea, finding that transitions to metamorphic development are associated with gene family expansions and functional convergence.

This study proposes a model of spatially varying diffusion to explain how the Bicoid gradient scales with embryo size in Drosophila, showing that gradient scaling arises from spatial heterogeneity rather than nuclear trapping.

This study identifies distinct transcriptional programs in zebrafish cranial motor neurons during development, showing that identity precedes axon targeting and is conserved across species.

The paper identifies three distinct follicle waves in Drosophila ovaries, with wave 1 germ cells contributing to an ecdysone pulse during pupal development.

The paper shows that Wnt and Nodal asymmetries contribute to left-right asymmetry in mice despite the absence of node flow, suggesting a novel mechanism for symmetry breaking.

The paper shows that GCL pruning of PIP3 regulates the soma-germline boundary by modulating Torso-dependent PI3K activity and Myosin II constriction in Drosophila embryos.

The paper investigates craniofacial genetic network evolution in syngnathid fishes using multiomics data, finding conserved core networks with localized changes contributing to morphological diversity.

This study creates a transcriptomic atlas of early Arabian killifish embryo development, identifying transcriptional modules across developmental stages and highlighting a delayed zygotic genome activation.

This paper shows how the spider venom gland evolved by integrating three distinct developmental programs: appendage patterning, secretory epithelium maintenance, and myogenic metabolism.

The paper identifies transcriptional regulators of abd-A and Abd-B in Drosophila adipocytes, revealing a feedback circuit involving Lola, Piragua, Seven up, and Wnt signaling that controls adipose tissue patterning.

This study identifies lateral inhibition as an ancestral mechanism for oil body cell patterning in liverworts, supported by fossil and extant species analyses.

The paper identifies temporally distinct CDX-driven regionalisation events that preconfigure vagal and trunk neural crest identities in mouse embryos.

This study identifies gluconeogenesis in the epidermis and endoderm of Xenopus tropicalis embryos, showing its role in development and highlighting tissue-specific metabolic diversity.

The paper shows that properly patterned zygotic genome activation (ZGA) is required for normal development and that embryos have a quality control system to detect and respond to mispatterned ZGA.

The paper shows that chromatin accessibility and co-factor availability determine ASCL1's ability to reprogram cells across different tissues in Xenopus embryos.

The paper introduces a mathematical model of Wnt-Dickkopf interactions in Hydra to explain body-axis formation through mutual inhibition, showing it can drive pattern formation across a broad parameter range.

This study shows that the Ecdysone Receptor (EcR) autonomously controls germ cell differentiation in Drosophila ovary stem cells and cystoblasts, with distinct roles in self-renewal and differentiation.

The paper identifies molecularly distinct cell populations in the zebrafish isthmic region using scMultiome and validates findings in vivo.

The paper shows LIN-66, a cold shock domain protein, works with microRNA pathways to control developmental timing by limiting early fate regulators' persistence.

This study reconstructs the evolutionary history of temporal transcription factor series in insect visual brains, showing conserved patterns and species-specific variations that influence neuronal diversity.

This paper introduces a computational framework to model limb skeletal patterning in mice and axolotls by integrating growth, gene regulation, and signaling spread, showing varying contributions of these factors across limb regions.

The paper shows that posterior abdominal tissue remodeling is essential for Drosophila male genital disc rotation, independent of the A7 segment.

The paper develops a platform for high-throughput CRISPRi screening in hPSC-derived organoids to identify genetic drivers of human anterior neural tube closure, finding ZIC2, SOX11, and ZNF521 as key regulators.

This study identifies Taqpep as a conserved mediator of periodic patterning in mammalian tissues, showing its role in both skin and intestinal development through mutant mouse models.

The paper compares cellular behaviours during insect gastrulation, finding divergent mechanisms between Drosophila and Tribolium, with nuclear crowding influencing internalisation modes.