Rebecca O’Rourke

The paper identifies molecularly distinct cell populations in the zebrafish isthmic region using scMultiome and validates findings in vivo.

This study identifies Gsx2 as a regulator of oligodendrocyte precursor cell formation in zebrafish spinal cord through single-cell and single-nuclei multi-omics analyses.

This study identifies the pericardium's origin from anterior mesothelial progenitors in zebrafish, distinct from the heart field, and links pericardial stiffness to pediatric cardiomyopathies.

The paper shows that specific odors can increase the birth rates of olfactory sensory neuron subtypes they activate in mice.

This study identifies meningeal-derived retinoic acid's role in suppressing Notch and Sox2 to regulate neurogenesis in neocortical progenitors.

The paper develops a co-culture model of human iPSC-derived neural organoids fused with mouse leptomeninges to study meninges-brain signaling and assesses its stability and utility.

The paper uses scMultiome analysis in zebrafish to identify mixed-identity progenitors in the embryonic hindbrain and shows their subdivision into distinct rhombomeres.

This study analyzes bulk, single-cell, and single nucleus transcriptomes of fetal and adult mouse rete ovarii to identify gene expression signatures and differences across RO regions.

The paper identifies Wnt-β-catenin signaling repression as key to arachnoid barrier cell specification in mouse meninges and shows its role in preventing pathogen entry during development.

This study identifies Hand2 as a key regulator of mesothelium progenitors in zebrafish and shows its reactivation in mesothelioma, linking developmental processes to disease.

The paper uses single-cell RNA sequencing to identify two distinct progenitor populations in zebrafish spinal cord pMN cells, one producing neurons and the other producing oligodendrocytes, marked by gsx2 expression.

The paper identifies three 3 UTR motifs that are required for mRNA localization to myelin sheaths in zebrafish.

The paper shows Prdm8 regulates the switch from motor neuron to oligodendrocyte production in zebrafish spinal cord by modulating Shh signaling.

This study creates a cellular atlas of developing meningeal fibroblasts in mice and humans, revealing distinct subtypes and their functional roles in CNS development.