Circadian rhythm and melatonin

The paper investigates daily electrical activity in the SCN of a diurnal mammal, finding day-night differences similar to nocturnal rodents but with a unique suppressive response.

This study investigates how temperature cycles affect circadian rhythms in Neurospora crassa, showing complex dynamics including entrainment, period-doubling, and aperiodic behavior through mathematical modeling.

This study investigates circadian rhythms in human intestinal organoids, showing circadian phase-dependent necrotic cell death responses to TcdB and identifying anti-phasic gene expression between mouse and human enteroids.

The paper introduces nCV, a method to assess circadian clock robustness in population-scale data without time labels, finding dampened oscillations in tumors.

pyActigraphy provides an open-source Python package for actigraphy data visualization and analysis, including sleep detection and rest-activity rhythm quantification.

The paper identifies rhythmic expression of Nf1 in Drosophila mushroom body neurons and shows its role in promoting daytime wakefulness through cAMP-PKA signaling.

The paper shows that the habenula clock modulates circadian variation in danger prediction, affecting anxiety-like responses to alarm pheromones in zebrafish.

The paper examines circadian regulation of visual transduction regulators in zebrafish and mice, finding rhythmic gene expression and physiological responses aligned with their diurnal/nocturnal activity patterns.

The paper shows that optogenetic activation of VIPergic SCN neurons mimics the effects of extended photoperiod on circadian rhythms and behavior.

This study shows that the SCN clock is sufficient to coordinate circadian sleep-wake cycles and improve sleep-dependent memory in clockless mice.

This study identifies INNEXIN2 as a gap junction protein that modulates the period of free-running rhythms in Drosophila melanogaster by affecting circadian pacemaker neuron function.

This paper uses machine learning to predict circadian gene expression in Arabidopsis using DNA sequence features, identifies key regulatory elements, and optimizes sampling strategies for circadian transcript prediction.

The paper uses genomic analysis to determine whether the pineal gland in Xenarthra is functional or vestigial, finding that melatonin synthesis and signaling genes are independently eroded and lost.

The paper shows that orexin A excites OPN neurons via OX2 receptor with higher responsiveness at night, and OPN firing increases during the day.

The paper uses daylight saving time as a natural experiment to study how genetic variation influences adaptation to abrupt time changes, finding differential effects based on morning or evening genetic predisposition.

The paper shows light affects mood-related behaviors in mice by inducing the clock gene Per1 in the lateral habenula, altering gene expression in the mesolimbic dopaminergic system.

This study shows clock proteins form dynamic nuclear foci that organize clock genes at the nuclear envelope to control circadian rhythms.

The paper validates a gene network model of the plant circadian clock by incorporating absolute transcription rates and testing against experimental data.

The paper shows that Venn Diagram analysis overestimates differentially rhythmic transcripts and introduces an R-package to improve accuracy in circadian rhythm studies.

This study identifies NCA-2 as a regulator of circadian period length in Neurospora by modulating intracellular calcium levels and affecting core clock component phosphorylation.

TimeCycle detects cycling transcripts in circadian time-series data using topology-based methods, showing effectiveness across various sampling schemes and data conditions.

This study shows that Per1 and Per2 are required for the daily rhythm of photoreceptor outer segment phagocytosis, with the RPE driving this process transcriptionally.

This study shows that deleting Per2 in glial cells of mice alters mood-related behaviors, reducing despair and anxiety with changes in neurotransmitter levels.

The paper shows that DMV neuronal activity varies daily and is modulated by diet, with high-fat diets paradoxically increasing daily variation but reducing responsiveness to metabolic neuromodulators.

This paper introduces likelihood-based methods to detect circadian rhythmicity and differential circadian patterns in transcriptomic data, showing improved error control and power in simulations and real data.

This study shows that higher daytime light intensity increases circadian rhythm amplitude in the diurnal rodent Rhabdomys pumilio by affecting SCN electrophysiological activity.

The paper creates a merged SBGN PD map of the circadian clock and cell cycle, validates its dynamics, and identifies NR1D1's role in regulating cell cycle progression.

This study examines how a 3-hour weekend light shift disrupts circadian rhythms in Drosophila, leading to desynchrony in neural networks and behavioral defects.

This study shows that Per1 and Per2 regulate myoblast differentiation and muscle regeneration through Igf2 activation, creating a circadian time window for these processes.

This study profiles the diurnal transcriptome of the benthic diatom Seminavis robusta, revealing rhythmic gene expression patterns and adaptations to its environment.