Circadian rhythm and melatonin

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper identifies cell-type-specific diurnal gene expression patterns in the mouse retina using single-nucleus RNA sequencing.

The paper evaluates methodological choices for analysing circadian activity data and identifies optimal approaches for different scenarios.

This study shows that high-intensity daylight exposure in the afternoon increases nighttime sleep intensity and reduces morning sleepiness without affecting circadian phase.

This study shows that loss of PEA-15 in mice affects circadian rhythms and ERK/MAPK signaling in the suprachiasmatic nucleus.

This study identifies genetic regulators of transcriptomic rhythmicity using GTEx data and links them to phenotypes in the Pan-UK Biobank.

This study identifies the neural circuitry regulating feeding-fasting rhythms in Drosophila larvae, showing that s-LNv and SIFa neuron interactions are critical for rhythm development.

This paper introduces PINN-iPRC, a neural network framework that infers infinitesimal phase response curves from finite-pulse circadian recordings, achieving accurate results comparable to specialized experiments.

The paper benchmarks 12 differential rhythmicity methods using synthetic RNA-seq data to guide method selection for time series analysis.

scRhythmBayes infers cell-level circadian phase and rhythm-state remodeling in single-cell transcriptomes, revealing distinct temporal patterns in liver zonation and heart disease.

This study identifies small molecules that bind to the PAS-A domain of CLOCK and NPAS2, stabilizing the domain and reducing DNA binding affinity of CLOCK:BMAL1.

The paper shows that chromatin states, not just circadian transcription factors, coordinate diurnal gene expression in Drosophila photoreceptor neurons by aligning gene phases with promoter, enhancer, or repressive chromatin signatures.

The paper investigates how cell state transitions in Prochlorococcus marinus MED4 affect transcriptome-proteome alignment through regulatory mechanisms involving RpaB and HimA.

This study identifies cwo/Dec1 as a molecular mechanism linking the circadian clock to lunar phase in Platynereis dumerilii, showing its role in circalunar oscillation.

The paper examines circadian modulation of pupil responses to different photoreceptor pathways and finds no support for circadian modulation of phasic pupil tracking.

This study benchmarks unsupervised circadian phase inference methods on bulk transcriptomic data, finding CHIRAL performs best with lower error than other methods.

This study examines transcriptional rhythmicity in aphids under different light and host conditions, finding limited rhythmic transcripts and host-dependent regulation.

The paper identifies novel membrane proteins in Drosophila circadian neurons and shows their roles in regulating locomotor rhythms under different photoperiods.

The paper benchmarks differential rhythmicity analysis methods and introduces a web platform for robust analysis and visualization of rhythmicity changes.

This study identifies a conformational switch in KaiA that regulates the day-night transition in cyanobacterial clocks and shows its role in maintaining rhythmicity.

This study shows that hyperglycaemia reversibly disrupts circadian behaviour in mice by reducing rhythm amplitude and altering phase, with effects reversed upon normoglycaemia restoration.

This study shows that the free-running period (FRP) length in Synechococcus elongatus affects the phase alignment of stress responses with environmental cues, enhancing survival under oxidative stress.

rhythmCI provides an R package for detecting circadian rhythms using harmonic regression confidence intervals, improving rhythmicity analysis in small clinical datasets.

The paper models the evolution of emergence patterns in Clunio insects using replicator-mutator dynamics, showing how phenotypic variability and environmental cycles influence population-level synchronization.

This study investigates how phosphorylation affects the CLOCK/BMAL1/nucleosome complex through structural and mechanical changes, revealing its role in circadian transcriptional repression.

The paper examines how circadian clock plasticity varies with latitude in 52 Drosophila species, finding distinct mechanisms in different subgenera.

This study uses a mathematical model to show that circadian clocks in Synechococcus elongatus enhance growth by enabling proteome adjustments that avoid inefficient nighttime growth.

The paper investigates the maturation of mRGC-mediated pupillary responses and circadian rhythms in human infants using pupillometry and sleep diaries, finding distinct developmental patterns for pupillary constriction and sleep/wake regulation.

This study identifies a distinct metabolomic signature in Drosophila under chronic social isolation, linking it to changes in sleep, feeding, and metabolism.

The paper shows that AMPK modulates circadian clock period and Bmal1 expression through NAD+-dependent mechanisms, validated by experiments and mathematical modeling.