Reproductive Biology and Fertility

This study identifies GC energy storage as a mechanism enabling avascular corpus luteum function by glycogen catabolism, with implications for reproductive health.

The paper uses morphokinetic analysis to classify bovine embryos into four blastocyst categories and identifies transcriptomic differences associated with genome activation.

The paper shows that protein accumulation upstream of Cdk1 activation regulates meiosis resumption timing and competence in oocytes through stepwise acquisition of regulatory mechanisms.

An engineered EGFR-targeting DARPin selectively inhibits ovulation through extracellular receptor blockade and establishes a versatile platform for investigating ovarian signaling and reproductive disorders.

This study uses spatial transcriptomics to show that aging disrupts spatial and temporal coordination of folliculogenesis in mouse ovaries, leading to tissue disorganization and reproductive decline.

The paper uses multimodal single-cell profiling to show how puberty and chemotherapy affect pediatric ovarian tissue, identifying vulnerabilities and a potential biomarker.

This study creates a comprehensive spatial atlas of the human ovarian cortex, revealing molecular mechanisms of primordial follicle activation and follicle niche organization.

The paper identifies maternal transcripts linked to zygote developmental potential and demonstrates their use in predicting blastocyst formation with high specificity.

This study shows that elamipretide improves oocyte quality and fertility in aged females by enhancing nuclear and cytoplasmic maturation through the VEGF signaling pathway.

This paper uses a microinjection-based single-oocyte assay to show that PFOS impairs oocyte maturation and early development by causing spindle defects, oxidative stress, and transcriptional dysregulation.

This paper describes a mouse line enabling conditional replacement of the LHR with GFP to study cell migration during ovulation.

This study creates a cross-species single-cell transcriptomic atlas of early ovarian development in cattle, human, and mouse, identifying shared and species-specific cell types and genes.

The paper identifies mechanisms of mitochondrial streaming in oocytes, showing actin-driven and chromatin-associated pathways that pattern mitochondrial distribution.

This study shows that inhibiting JNK in oocytes protects against chemotherapy-induced infertility and ovarian hormone loss in mice.

This study shows that Camsap3-mediated microtubules are essential for maintaining transzonal projections (TZPs) in mouse ovarian follicles, ensuring proper germline-soma communication during follicle maturation.

This study shows glucose regulates trophectoderm differentiation in bovine embryos through Hippo signaling via HBP and PPP, not glycolysis.

This study shows that chronic unpredictable mild stress induces age-dependent ovarian aging and POI in young and middle-aged female mice, with distinct endocrine and transcriptomic responses.

This study shows that adding L-proline to embryo culture media increases intracellular glutathione levels, reducing oxidative stress in preimplantation mouse embryos.

The paper proposes a stochastic mechanism for dominant follicle selection, showing how FSH and estradiol interact to ensure single follicle selection through negative feedback.

This study shows that vitrification and warming of mouse embryos cause developmental delays and impair mitochondrial function and cytoplasmic lattice integrity.

This study uses ex vivo live imaging to observe oocyte formation dynamics in mice, revealing blebbing activity during mitosis-to-meiosis transition and no organelle transfer between germ cells.

This paper validates a CUBIC-based workflow for volumetric analysis of follicles and vasculature in human ovarian tissue, showing comparable follicle density to histology and detailed vascular morphometrics.

Bovine oviductal organoids treated with estradiol or a progesterone analog reproduce follicular and luteal transcriptomes and secretomes; estradiol-stimulated secretions boost bull sperm capacitation and acrosome reaction.

The paper identifies GPLD1 as the enzyme mediating JUNO shedding in porcine oocytes, which is critical for preventing polyspermy and improving IVF outcomes.

This study identifies NFYA as a regulator of two sequential transcriptional activation events during oocyte-to-embryo transition, showing its role in primordial follicle activation and zygotic genome activation.

This study identifies selective transcriptomic vulnerabilities in neural tissues during vitrification, showing under-representation of membrane-integrated transcripts in the hippocampus.

This paper introduces a rapid in vitro system for analyzing maternal effect genes during mouse oocyte growth using microinjection and culture, showing effective gene manipulation without compromising developmental competence.

This study reanalyzes single-cell RNA sequencing data to show that mitochondrial gene expression changes precede oxidative phosphorylation activation and lineage specification in human pre-implantation embryos.

This study shows ovarian macrophages regulate germ cell meiotic entry, vascular growth, and germ cell clearance during oocyte reserve establishment.