Reproductive Biology and Fertility

This paper introduces a method to generate oviductal assembloids from mouse and human tissues to study oviduct function and embryo-maternal interactions in vitro.

This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

This study identifies MATR3's role in oocyte growth and maturation through transcriptional regulation and paracrine signaling, showing its importance in fertility and potential as a therapeutic target for OMA.

The paper identifies a novel RNP compartment in mouse oocytes that enhances translation to counteract cytoplasmic dilution during growth.

The paper identifies age-related mitochondrial subpopulation changes in oocytes and cumulus cells and shows NMN has subpopulation-specific effects.

This study identifies proteomic differences between in vivo and in vitro matured mouse oocytes, revealing dysregulated pathways in in vitro systems and conserved patterns in human oocytes.

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

This study identifies GC energy storage as a mechanism enabling avascular corpus luteum function by glycogen catabolism, with implications for reproductive health.

This study uses spatial transcriptomics to show that aging disrupts spatial and temporal coordination of folliculogenesis in mouse ovaries, leading to tissue disorganization and reproductive decline.

This paper describes a mouse line enabling conditional replacement of the LHR with GFP to study cell migration during ovulation.

The paper identifies mechanisms of mitochondrial streaming in oocytes, showing actin-driven and chromatin-associated pathways that pattern mitochondrial distribution.

This study shows that Camsap3-mediated microtubules are essential for maintaining transzonal projections (TZPs) in mouse ovarian follicles, ensuring proper germline-soma communication during follicle maturation.

The paper proposes a stochastic mechanism for dominant follicle selection, showing how FSH and estradiol interact to ensure single follicle selection through negative feedback.

This study shows that vitrification and warming of mouse embryos cause developmental delays and impair mitochondrial function and cytoplasmic lattice integrity.

This study uses ex vivo live imaging to observe oocyte formation dynamics in mice, revealing blebbing activity during mitosis-to-meiosis transition and no organelle transfer between germ cells.

Bovine oviductal organoids treated with estradiol or a progesterone analog reproduce follicular and luteal transcriptomes and secretomes; estradiol-stimulated secretions boost bull sperm capacitation and acrosome reaction.

This study shows that EGG-1 and EGG-2 are not required for fertilization in C. elegans but are involved in post-fertilization processes like eggshell integrity and embryo protection.

Hydrogels matching aged mouse ovary stiffness (5.85 kPa vs 0.84 kPa) cut follicle survival to 6.66% to 30%, reduce estradiol up to 533-fold, and alter 135 genes within 6 hours.

This study shows that mild restraint stress in mice prolongs the diestrus phase of the estrous cycle, suggesting that moderate stress may disrupt reproductive cycling.

This study shows that encapsulated human ovarian xenografts restore endocrine function in ovariectomized mice, integrating with the host's hypothalamus-pituitary-gonad axis and maintaining cyclicity and hormone levels.

The paper develops and applies transvaginal ovum retrieval techniques in scimitar horned oryx and roan antelope to support assisted reproductive technologies for conservation.

This study shows that adding extracellular vesicles from follicular fluid to in vitro maturation culture improves oocyte maturation rates and alters proteome and ultrastructure.

The paper profiles inorganic elements in mouse embryos and shows zinc supplementation during blastocyst formation increases Nanog expression in the inner cell mass.

This study identifies early gonadotoxic effects of cyclophosphamide on prepubertal testes and shows antioxidant co-treatment can reduce toxicity without compromising anticancer efficacy.

This study develops ovarian somatic organoids that maintain cellular diversity and reveal age-related changes in cellular composition and function.

The paper shows that a balanced DNA-to-cytoplasm ratio, rather than genome ploidy, is critical for mouse embryos to reach the morula stage.

This study shows that the zinc transporter Zip10 is essential for zinc sparks during fertilization in mice, which are critical for embryo development.

This study uses imaging and analysis to reveal the roles of the zona pellucida and perivitelline space in gamete fusion and polyspermy block in mice oocytes.