Chronic Kidney Disease and Diabetes

The paper identifies altered protein translation and carboxylic acid catabolism in diabetic kidney disease using human and mouse models.

The paper identifies changes in olfactory receptor expression during kidney fibrosis progression using systems biology and experimental validation in a mouse model.

This study uses multimodal single-cell sequencing to show that chromatin accessibility and genetic background influence diabetic kidney disease progression through cell-specific mechanisms.

The paper identifies peroxisomal dysfunction as a key feature of early diabetic kidney disease through proteomic analysis in mice and human samples.

The paper develops a mathematical model to study how collagen deposition in diabetic kidney disease affects intercellular signaling, finding that it can enhance signaling range rather than diminish it.

This study examines the association between HBA copy number and kidney disease risk in Black Americans, finding higher HBA copy number linked to increased CKD prevalence and ESKD incidence.

The paper identifies p21 as a key mediator of hyperglycemic memory in diabetic kidney disease and shows that aPC signaling can reverse its effects.

This study shows that overexpressing DsbA-L in adipose tissue protects against diabetic kidney damage by reducing inflammation and improving kidney function through the adipo-renal axis.

This study shows that Roux-en-Y Gastric Bypass Surgery reduces renal injury in diabetic rats by altering fibrosis, inflammation, and TGF-β pathways in the kidney.

This study investigates the role of GPR109a in diabetic nephropathy by examining its effects on renal injury and intestinal permeability in Gpr109a-/- mice.

The paper shows miR-9-5p protects against kidney fibrosis by reprogramming metabolism and mitochondrial function in a mouse model.

This study uses snRNAseq to analyze early diabetic nephropathy in human kidneys, identifying gene expression changes in potassium secretion and angiogenic signaling across multiple cell types.

This study shows emodin reduces renal interstitial fibrosis in rats by modulating the TIMP1/MM9 pathway.

This study identifies 16 genome-wide significant loci associated with diabetic kidney disease, including a protective variant in the COL4A3 gene.

This study uses EMRs and GWAS data to map CKD progression trajectories in African Americans with type 2 diabetes, identifying high-risk and low-risk pathways linked to APOL1 genotypes.