Chronic Kidney Disease and Diabetes

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.

Proteomics of highly post-translationally modified proteins in kidney tubulointerstitium

This study quantifies matrisome proteins and their post-translational modifications in kidney tubulointerstitium from human biopsies to understand interstitial fibrosis and tubular atrophy progression.

Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment

This study shows that high glucose in kidney organoids causes inflammation and epithelial detachment, which can be reversed by targeting cytokines and signaling pathways.

Disease progression Mendelian randomization of risk factors for kidney function decline in chronic kidney disease and the general population

This study uses Mendelian randomization to identify risk factors for kidney function decline in CKD and the general population, finding causal effects of type-2 diabetes and high TSH.

Deep visual proteomics reveals distinct proximal tubular and glomerular injury programs in experimental diabetic kidney disease

This study uses deep learning to analyze proteomic data from mouse kidney compartments, revealing distinct injury programs in proximal tubules and glomeruli in diabetic kidney disease.

Systems-level proteomic reprogramming reveals mitochondrial restoration and inhibition of Rho GTPase-mediated cytoskeletal and inflammatory signaling in CKD

This study uses proteomic analysis to show DVA treatment restores mitochondrial function and suppresses inflammatory and oxidative stress pathways in CKD.

Model-Dependent Renal Phenotypes in Diabetic Kidney Disease: Comparative Histopathological Characterization of Commonly Used Animal Models

This study compares histopathological features of three diabetic kidney disease models, finding that Akita and STZ models show clear structural changes while db/db models require electron microscopy for accurate assessment.

Circulating soluble urokinase-type plasminogen activator receptor reflects disease severity in a mouse model of diabetic kidney disease and heart failure with preserved ejection fraction

The paper evaluates biomarkers in a mouse model of diabetic kidney disease and HFpEF, finding that suPAR levels correlate with disease severity.

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosis

This study identifies Fibulin-2 as a matrix cue that transduces fibrotic ECM remodeling into mitochondrial metabolic reprogramming in kidney fibrosis.

A multi-omics map of diabetic nephropathy links c-Jun activation to tubular injury and metabolic stress

This study integrates multi-omics data to identify c-Jun as a key driver of tubular injury and fibrosis in diabetic nephropathy.

Applying Spatial Statistics to Spatial Transcriptomics Reveals Local Association Between M2-like Macrophages and Fibrosis in Diabetic Kidney Disease

This paper applies geographically weighted regression to spatial transcriptomics data to identify spatially coupled M2 macrophages and fibrosis in DKD, finding enriched IgE-related genes in high-coupling spots.

Multi-state Continuous-Time Markov Chain Modeling for Chronic Kidney Disease Progression

This paper develops a CTMC framework for modeling CKD progression using synthetic EHR data, showing improved log-likelihood and stage-specific associations with male sex and hypertension.

Ageing impacts extracellular matrix turnover and remodelling in the kidney

This study quantifies age-related changes in kidney extracellular matrix turnover and identifies structural and functional alterations linked to fibrosis.

Multimodal predictions of end stage chronic kidney disease from asymptomatic individuals for discovery of genomic biomarkers

The paper predicts end-stage renal disease from asymptomatic individuals using multimodal data and identifies novel genomic biomarkers associated with kidney function and disease risk.

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

Empagliflozin preserves mitochondrial function and reduces tubular injury in obese type 2 diabetic ZSF-1 rats

A High-fat, High-salt Diet Model of MDAKD Impairs Bioenergetic Efficiency for ATP Synthesis

This study shows a high-fat, high-salt diet induces early MDAKD-like kidney injury in mice, with strain-specific mitochondrial dysfunction and fibrosis.

HuR inhibition attenuates hypertension and fibrosis in chronic kidney disease

This paper shows that inhibiting HuR reduces hypertension and fibrosis in chronic kidney disease by targeting inflammation, oxidative stress, and vascular dysfunction.

ADAM17 Deletion Protects Against Type1 Diabetes-Associated Kidney Injury by Modulating Inflammatory and Fibrotic Pathways

This study shows that deleting ADAM17 globally protects against diabetes-induced kidney injury by reducing inflammation and fibrosis in a mouse model.

Dapagliflozin mitigates hypoxia-induced metabolic stress, kidney tubular cell death and fibrosis

This study shows dapagliflozin reduces hypoxia-induced metabolic stress, cell death, and fibrosis in kidney organoids derived from human pluripotent stem cells.

Investigating the Mitochondria-Related Mechanisms of Ligustri Lucidi Fructus in Treating Diabetic Nephropathy: A Combined Approach of Network Pharmacology, Transcriptomics, and Experimental Validation

TNFα and Endothelial IL-1 Receptor Signaling Drive Peritubular Capillary Regression and Fibrosis in Obstructive Kidney Injury

This study identifies TNF and endothelial IL-1R1 signaling as key drivers of capillary regression and fibrosis in obstructive kidney injury, showing that their combined inhibition preserves peritubular capillaries and reduces renal injury.

Claudin-1 Inhibitor PDS-0330 Ameliorates Diabetic Kidney Disease by Suppressing Src/Akt/mTOR Signaling Pathway in Podocytes

This study shows that the claudin-1 inhibitor PDS-0330 reduces urinary albumin excretion and attenuates Src/Akt/mTOR signaling in podocytes of diabetic mice.

Defective insulin clearance plays a primary role in the pathogenesis of chronic kidney disease in mice with null deletion of Ceacam2 gene

This study shows that loss of CEACAM2 in mice impairs renal insulin clearance, leading to hyperinsulinemia, insulin resistance, and kidney dysfunction.

Artesunate Alleviate Kidney Fibrosis by Restoring Klotho Protein and Suppressing Wnt/β-Catenin Signalling Pathway

This study shows artesunate reduces kidney fibrosis by restoring Klotho protein and inhibiting the Wnt/β-catenin pathway in both mouse and human models.

Multi-Cellular Network Model Predicts Alterations in Glomerular Endothelial Structure in Diabetic Kidney Disease

This study uses a logic-based network model to predict how glucose signaling dysregulation affects glomerular endothelial cell fenestrations in diabetic kidney disease.

A murine model of cardiovascular-kidney-metabolic syndrome demonstrates compromised limb function in the ischemic hind limb

This study develops a murine model of cardiovascular-kidney-metabolic syndrome by combining high-fat and adenine diets, showing impaired limb function and metabolic complications.

SGLT2 Inhibition Ameliorates Age-Dependent Renovascular Rarefaction

This paper shows that SGLT2 inhibition reduces age-related vascular rarefaction and preserves renal function in African turquoise killifish.

The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation

This study shows that Finerenone reduces kidney disease in mice by improving mitochondrial function, lowering lipid accumulation, and reducing inflammation.

D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis

This study identifies Glce as a key regulator of kidney fibrosis by binding to EGFR and inhibiting EMT through the TGF-β/Smad pathway, independent of its enzymatic activity.