Reproductive tract infections research

This study shows that seminal plasma inhibits Chlamydia trachomatis infection and modulates neutrophil function in an in vitro model of the female reproductive tract.

The paper uses 2CMC to clear TVV infections in Trichomonas vaginalis isolates, revealing differential drug susceptibility among TVV species and enabling the generation of isogenic clones.

This study identifies Prevotella as a major source of sialidases in the vaginal microbiome, showing their prevalence and activity compared to Gardnerella.

This study infects human intestinal organoids with Chlamydia trachomatis, showing resistance to apical infection and basolateral entry, and identifies Pgp3 as a key virulence factor.

This study identifies P. timonensis as a BV-associated bacterium with high mucin-degrading enzyme activity that removes protective glycocalyx sugars from vaginal epithelium.

This study classifies vaginal microbiome dynamics into four types using daily samples and identifies factors like phage abundance and bacterial strains that influence these dynamics.

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

This study shows that ectopic expression of the chlamydial transcriptional regulator Euo arrests developmental progression at an early Intermediate Body stage but does not affect the formation of the infectious Elementary Body.

This study identifies two short linear motifs in Chlamydia effector IncE that reprogram host vesicle trafficking to support bacterial replication.

This paper develops a qRT-PCR test targeting 22 BV-associated species and uses it to create a diagnostic index that classifies vaginal microbiome states into BV-positive, BV-negative, or transitional BV.

This study links cervicovaginal microbiome composition to hrHPV infection outcomes in a longitudinal cohort, showing specific microbial patterns associated with SIL development.

This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

This study investigates how Neisseria gonorrhoeae colonizes macrophages under different polarization states and nutrient conditions, finding that invasion occurs across all activation states with lower efficiency in M1-like macrophages.

This study shows that high-fat, low-fiber diets promote vaginal GBS persistence in mice, highlighting diet's role in shaping vaginal microbiota and influencing colonization resistance.

This study links affective symptoms during pregnancy to vaginal microbiome composition, showing associations with specific taxa and metabolic pathways.

This study analyzes longitudinal vaginal microbiome data from diverse ethnic groups, revealing ethnic signatures in microbial diversity, community states, and evolutionary dynamics, with Lactobacillus adhesins showing positive selection.

This study analyzes genomic variation in Chlamydia trachomatis serovars A and B from Gambian trachoma-endemic villages to understand strain diversification and evolutionary pressures.

This study uses neural differential equations to predict preterm birth from vaginal microbiota data, achieving better performance than traditional machine learning methods.

This study uses a manifold-based framework to analyze 8,026 vaginal samples and identify progression routes from healthy to bacterial vaginosis (BV) states, revealing key taxa and health indicators.

This study shows that female sex hormones regulate vaginal microbiota colonization in mice, with estrogen promoting bacterial persistence and glycogen production.

This paper reports antimicrobial susceptibility and genomic data of Neisseria gonorrhoeae isolates from Madagascar, identifying resistance patterns and genetic mechanisms.

The paper screens 140 chlamydial antigens in mice to find subunit vaccine candidates, finding none effective but identifying pathogenic antigens and showing viable organisms induce better immunity.

This paper identifies Chlamydia trachomatis-induced YAP activation in cervical epithelial cells as a driver of fibrosis through paracrine signaling to fibroblasts.

This study shows that Gardnerella vaginolysin releases host cell contents that enhance Neisseria gonorrhoeae's ability to mimic host glycans and evade immune detection.

The study examines the cervical microbiota of Hispanic women in Puerto Rico, finding it dominated by L. iners regardless of HPV status, with no significant microbiota-HPV associations.

This study profiles the vaginal microbiome of Chinese women during pregnancy and 6 weeks postpartum, identifying variations linked to medical history and pregnancy outcomes.

The paper characterizes the vaginal microbiome and sialidase activity in 2689 Chinese pregnant women, finding no association with preterm birth risk.

This study uses microbial topic modeling to identify associations between vaginal microbiome composition and intrapartum fever in Ugandan laboring women, improving prediction beyond clinical variables.