Carcinogens and Genotoxicity Assessment

This study evaluates the genotoxicity and 90-day oral toxicity of a high-purity mogroside preparation from monk fruit, finding it non-mutagenic and non-clastogenic with no adverse effects at the highest tested dose.

This study quantifies DNA adduct formation in mice exposed to ethylene oxide, showing dose-dependent differences between two adducts and their implications for cancer risk assessment.

MutAIverse detects known and novel DNA adducts and their precursor genotoxins using an AI-driven platform with mechanistic modeling and spectral mapping.

This study investigates the dose-response relationship of ethylene oxide-induced genetic damage in mice to assess its potential carcinogenicity through a mutagenic mechanism.

The paper applies BMD modeling to NDMA datasets to support the cumulative dose assumption in the LTL-TTC framework, showing short-term assays can predict long-term carcinogenicity.

This paper introduces a method to calibrate chemical-agnostic quantitative adverse outcome pathways (qAOPs) by separating chemical-specific heterogeneity from pathway effects, improving their reliability across multiple chemicals.

This study identifies persistent interferon signaling and clonal expansion as early events in NDMA-induced liver cancer by analyzing molecular changes in mice.

This review analyzes variability and uncertainty in genotoxicity test guideline data, highlighting challenges in integrating non-animal methods into regulatory frameworks.

This study tests the genotoxicity of ten pesticides and their mixtures on Caco-2 cells using micronucleus assays, finding genotoxic effects in several individual pesticides and some mixtures.

This paper evaluates the genotoxic potential of three dietary metabolites of fludioxonil using a tiered approach involving (Q)SAR, read across, and various in vitro and in vivo genotoxicity assays, concluding they pose no genotoxic concern.

The paper assesses DNA content and damage in raw and heat-processed foods, finding significant DNA damage increases from cooking and potential cytotoxic effects in human cells.

The paper develops an LC-MS/MS method to quantify NNAL-specific protein adducts in biological samples to assess tobacco exposure and estimate NNAL bioactivation.

This study evaluates the genotoxic and toxicological safety of Anaerostipes caccae CLB101 in rats, finding no adverse effects at doses up to 1000 mg/kg bw/day.

This study aligns Duplex Sequencing with transgenic rodent mutation assay data to assess in vivo NDMA-induced mutagenesis, finding dose-dependent mutation frequency increases and concordant benchmark dose estimates.

This study shows exposure to urban sediments containing TRWPs increases mutation rates in Chironomus riparius by 50%, with mutational profiles similar to those caused by Benzo[a]Pyrene.

The paper introduces a protocol to quantify DNA damage in individual dormant eggs using the comet assay, showing its effectiveness for assessing DNA integrity in sedimentary archives.

This study shows that neutral lipids in the nucleoid restrict DNA migration in comet assays and may regulate DNA dynamics in the nucleus.

This study assesses the mutagenic and clastogenic effects of benzo[b]fluoranthene in mice using Duplex Sequencing and the micronucleus assay, showing dose-dependent increases in mutation frequency and cancer-related mutation spectra.

This study assesses the toxic effects of a KEAA fuel blend on A549 lung cells using air-liquid interface exposure and finds no adverse effects within tested concentrations.

This paper develops a support vector machine-based model to predict genotoxic hepatocarcinogens in rats using gene expression data from a single dose and day of exposure.

The paper screens yeast for resistance to a carcinogen, identifies genes linked to colon cancer, and suggests potential mechanisms for HAA toxicity.

The paper shows environmental carcinogens like PAHs disproportionately mutate genes linked to neurodevelopmental disorders such as ASD and schizophrenia.

This paper evaluates a DuplexSeq-based mutagenesis assay in ENU-exposed rats, showing early detection of mutations and reproducible results across tissues and labs.

This study uses Duplex Sequencing to assess mutation frequencies and spectra in MutaMouse bone marrow after procarbazine exposure, showing its advantages over conventional assays.

The paper develops a high-throughput mutagenesis assay using DNA-barcoded supF shuttle vectors and NGS to study mutation frequencies and spectra in E. coli.

This study analyzes mutational patterns induced by formaldehyde and acetaldehyde, revealing similarities to a known mutational signature and distinguishing features between the two compounds.

The paper develops Metabokiller, an AI model that predicts carcinogenic human metabolites by analyzing their biochemical properties and validates predictions through experimental assays.

This study shows acetaldehyde causes strand-biased G[->]T mutations on single-stranded DNA via Polζ bypass and identifies a unique mutation signature in alcohol-related cancers.

This paper demonstrates that Duplex Sequencing, an error-corrected NGS method, can accurately quantify in vivo mutagenesis and early signs of carcinogenesis in mice, outperforming traditional transgenic rodent assays.