Memory and Neural Mechanisms

This study estimates memory capacity in heterogeneous neural networks and finds that maximizing capacity requires correlations between inward connections and coding levels in brain-inspired models.

The paper investigates the role of ventral hippocampus and nucleus accumbens core and shell in destabilizing well-learned instrumental memory in rats, finding only the core is involved.

The paper investigates the direction of communication between the hippocampus and parahippocampal cortex using fMRI, finding that predictions are communicated from the hippocampus to deep layers of the parahippocampal cortex.

The paper mathematically proves that spatial periodicity in grid cell firing is the only solution to a neural sequence code for 2-D trajectories, explaining the hexagonal firing pattern and its functional role.

The paper shows error-driven drift in hippocampal representations enables flexible re-learning by allowing new associations to form while maintaining previous ones in synaptic weights.

This study shows that hippocampal sharp-wave ripples (SWRs) decrease during physical actions and consummatory behavior in immobile rats, challenging the idea that SWRs are specific to consummation.

This study shows that hippocampal time cells adapt their dynamics during learning to reflect cognitive demands related to temporal context discrimination.

This paper introduces a computational model to explore how alcohol affects fear conditioning by simulating amygdala circuit changes and their impact on fear extinction.

This study shows that NPTXs regulate engram network stability, and their downregulation in aging leads to memory deficits by causing hyperactivity in memory-related neuronal ensembles.

NaviGraph is a graph-based framework for analyzing spatial decision-making by integrating multimodal data, revealing subtle recall impairments in ApoE4 mice.

The paper shows that re-enacting movement patterns during memory retrieval improves distance estimation by correcting path integration errors in grid cells.

The paper shows that practice optimizes neural representational geometry to enhance task performance by stabilizing and aligning conjunctive neural states that abstract over non-critical task features.

The paper shows that dmPFC neurons encode internal models of emotional associations, linking sensory stimuli with aversive events directly or indirectly.

This study shows the hippocampus integrates spatial cues during navigation, with stronger positional coding when combining landmarks and self-motion cues, suggesting a role beyond simple spatial representation.

The paper shows that coherent thalamic head direction signals from the anterodorsal nucleus influence medial entorhinal cortex coordination during wakefulness and sleep.

This study investigates how the estrous cycle affects hippocampal spine dynamics, dendritic processing, and spatial coding in female mice using in vivo imaging.

This study shows that cholinergic blockade disrupts hippocampal theta oscillations during memory encoding but not retrieval, suggesting theta reflects an encoding state rather than being required for retrieval.

The paper examines individual differences in fear memory expression in zebrafish, identifying distinct brain networks associated with different behavioral responses.

The paper identifies two distinct visual escape behaviors and their neural pathways, revealing how the mediodorsal thalamus modulates arousal and defensive responses to repeated threats.

The paper identifies a neural circuit in the insular cortex crucial for non-nociceptive fear learning using a visual threat paradigm in mice.

This study investigates olfactory reversal conditioning in humans and finds no significant physiological or behavioral differences between conditioned and unconditioned odors.

The paper shows that striatal activity is required for trial-to-trial learning improvements but not for memory recall.

This study identifies D1 and D2 dopamine receptor-expressing neurons in the mouse ventral hippocampus and shows they mediate opposing approach/avoidance behaviors during anxiety-related tasks.

The paper shows that hippocampal-entorhinal circuits and SMA represent action plans and their outcomes, with hippocampal activity scaling with outcome similarity and SMA responding to overlapping actions.

This study shows that instrumental reward learning increases intrinsic excitability of BLA projection neurons, while punishment training maintains excitability and response-independent shocks reverse it.

This study shows MMP-2/9 inhibition affects SWR abundance, fear memory, and sociability in juvenile zebrafish, with implications for affective disorders.

This study investigates how backward conditioned suppression is influenced by GABA-A receptor modulation and BNST GABA neurons in mice.

This study shows that early-life experiences during a sensitive period influence the timing of episodic-like memory development in mice by modulating perineuronal net formation.

This study identifies a ventral CA2 region in the hippocampus that promotes social aggression but not social memory, distinguishing it from the dorsal CA2 region.

The study shows that infralimbic cortex, but not prelimbic cortex, is required for resolving retroactive interference in a complex olfactory memory task.