Memory and Neural Mechanisms

The paper identifies a two-phase neural code in hippocampal CA1 pyramidal neurons that encodes time and distance, linking spatiotemporal integration to predictive behavior.

This study shows that the hippocampus enables rapid generalization in mice through disentangled memory representations and structured circuit dynamics.

The paper identifies differences in glutamatergic inputs and dendritic spine density between Semilunar Granule Cells and Granule Cells in the dentate gyrus, suggesting functional diversity.

This study investigates the functional connectivity of the Reuniens nucleus to the medial prefrontal cortex, revealing prolonged recurrent excitation and potential roles in memory formation.

The paper uses artificial neural networks to model how the human amygdala processes sensory inputs and relates them to self-reported valence in naturalistic stimuli.

This paper introduces a context-modular memory network model that enhances memory capacity through context-dependent neuronal and synaptic gating, showing improved stability and accessibility of memory patterns.

The paper identifies a population code in VMHdmSF1 neurons that encodes predator imminence and internal states during predator encounters in mice.

The paper investigates how the human hippocampus and medial prefrontal cortex represent abstract boundaries in memory-guided tasks and finds that the hippocampus flexibly encodes these boundaries, influencing choice behavior.

The paper investigates how propofol affects memory consolidation of schema-congruent and -incongruent information, finding enhanced consolidation of schema-congruent items.

This study identifies distinct roles of AHN neuron subtypes in mediating different stages of defensive behaviors through optogenetic and fiber photometry approaches.

This study shows ARIH1 deficiency impairs spatial learning and memory in mice by increasing GIRK2 in hippocampal CaMKII neurons, which can be reversed by GIRK inhibition.

This paper challenges the interpretation of hippocampal firing field shifts as evidence for space-time integration by proposing an alternative model based on velocity integration.

This study shows that the hippocampus maintains a hierarchical representation structure during learning but modifies lower-level representations to improve context decoding and learning efficiency.

This study investigates hippocampal theta oscillations during real-world and imagined navigation, showing similar neural patterns and using a computational model to reconstruct imagined positions.

This paper introduces MoHA, a model that integrates motivational and visual inputs to generate cognitive maps, enabling adaptive navigation in reinforcement learning agents.

This study shows that distinct subregions of the medial prefrontal cortex bidirectionally regulate emotional memory extinction through their influence on the locus coeruleus-noradrenaline system.

The paper identifies distinct noradrenergic subsystems in the locus coeruleus that dynamically respond to varying levels of social stress, influencing traumatic learning and anxiety.

The paper introduces ThermoMaze, a behavioral paradigm that enables the study of brain activity during immobility by leveraging mice's warmth-seeking behavior and combines it with electrophysiology.

The paper examines how different cell types in the ventral hippocampus encode anxiety-related information during an anxiety test, finding distinct encoding patterns in granule cells and mossy cells.

This paper demonstrates that certain and uncertain threat anticipation recruit a shared neural circuit with distinct activation dynamics in humans.

The paper investigates how hippocampal neurons track multiple agents during pursuit tasks, finding multiplexed neural maps and semi-orthogonal subspaces for distinguishing agents.

This study shows acetylcholine in the medial prefrontal cortex modulates how mice encode unexpected outcomes during threat learning, affecting decision-making under uncertainty.

This study shows that serotonin signaling in the rat prefrontal cortex is critical for retrieval-induced forgetting, with specific receptor subtypes modulating memory competition.

The paper shows that human hippocampal neurons encode visual sequences through population-level ring topologies that preserve temporal order.

The paper uses ethograms to show that a fear conditioned visual cue in rats suppresses reward seeking and elicits freezing, with classification accuracy improved by full ethogram data.

This study examines how a rat model of Fragile X Syndrome affects hippocampal place cell coordination during active behavior and rest, finding impaired sequence activation and replay.

This paper develops a VAE model with RNNs to study neural mechanisms of perspective transformation between first-person and global map views, finding that temporal sequences and proximal cues are critical.

IntelliR is a pipeline for analyzing IntelliCage data, enabling automated assessment of spatial, episodic-like, and working memory in mice, with validation using control and neuron-ablated cohorts.

The paper shows that hippocampal place field remapping and coordinated ensemble activity, dependent on protein synthesis, are critical for contextual fear memory consolidation.

This study shows that adolescent alcohol exposure alters perineuronal net (PNN) expression in the infralimbic cortex, reducing the effectiveness of PNN digestion to enhance fear extinction.