Nerve injury and regeneration

This study identifies TIR-1/SARM1 as a dual regulator that inhibits axon regeneration while promoting degeneration, revealing distinct pathways for each function.

The paper shows that Schwann cells guide axon sorting at a nerve plexus during regeneration, restoring target-specific connectivity in zebrafish.

This study shows that membrane association of Stmn2 is critical for axon protection, mediated by palmitoylation and tubulin interaction, and reveals a role for DLK in regulating Stathmin abundance in axons.

The paper creates an atlas of injured sciatic nerve cells and identifies immune microenvironments and communication networks in mouse nerve regeneration.

This study shows that reducing NMN levels in Drosophila prevents axon degeneration and neurodegeneration, revealing NMN's role in axon injury and disease.

This study shows that senescent Schwann cells, induced by aging and chronic denervation, impair axonal regeneration by reducing c-Jun expression and secreting inhibitory factors, and that eliminating these cells improves regeneration.

This study identifies proteomic changes in human sural nerve after transection injury, revealing upregulated and downregulated proteins associated with regeneration and degeneration.

The paper identifies glial TGFβ signaling as essential for axon survival and shows its loss leads to age-dependent neurodegeneration.

This study shows that inhibiting VASH1/2 with parthenolide or its prodrug DMAPT promotes axon regeneration in injured nerves across species, suggesting potential therapeutic applications for nerve injuries.

This study shows that overexpressing eEF1A2 promotes corticospinal axon sprouting after injury by enhancing protein synthesis, mTOR signaling, and actin rearrangement.

The paper uses STED microscopy to analyze MPS formation in axons and regenerating axons, finding faster MPS development in regenerating axons and effects of calpain inhibition.

The paper investigates how modulating neuronal activity with opto- or chemogenetics affects axonal growth after injury, finding that growth is enhanced only on permissive substrates.

This study identifies the RSK2-RPS6 axis as essential for preconditioning and regeneration in both PNS and CNS neurons, showing its role in axon growth and functional recovery.

This study develops a photo-switchable assay to study dendrite degeneration and repair in Drosophila, revealing that WldS and dSarm1 modulation affects dendrite recovery.

This study investigates whether injury-induced enhancers in Schwann cells are pre-programmed or activated de novo, and identifies JUN's role in regulating these enhancers to drive repair gene expression.

The paper identifies REST/NRSF as a suppressor of CNS axon regeneration using systems biology approaches and validates its role through genetic manipulations.

This study investigates the roles of DLK and LZK in axon regeneration and sprouting in zebrafish neurons, finding context-dependent effects on different neuron types.

The paper identifies transcriptional programs that enhance survival and axon regeneration of injured retinal ganglion cells using single-cell transcriptomics and computational analysis.

This study shows that presynaptic terminals in regenerating axons rapidly mature functionally after re-contact, becoming indistinguishable from controls within a week.

Genetic or HF-rTMS activation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration after spinal cord injury.

The paper investigates the role of the canonical Wnt signaling pathway in PNS regeneration and finds that manipulating it does not enhance regeneration.

This study introduces a system that forces membrane localization of TrkB's intracellular domain to achieve constitutive activation, enhancing neuroprotection and axon regeneration in glaucoma models.

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

The paper examines the expression of GDNF receptors in the nucleus ambiguus of developing rat brains and finds differential upregulation patterns across embryonic stages.

This study shows that co-targeting B-RAF and PTEN in adult mice enhances dorsal column axon regeneration across and beyond spinal cord injury.

This study shows that miR-182-5p downregulates Nogo-A expression and promotes neurite outgrowth in hippocampal neurons, suggesting its potential as a therapeutic tool for CNS regeneration.

This study shows that pleiotrophin (PTN) promotes neurite outgrowth in neurons exposed to inhibitory CSPG matrix via ALK receptor activation.