Nerve injury and regeneration

This study investigates the developmental timing and regional specificity of long-distance axon growth in the spinal cord using a novel lesion paradigm.

This study identifies Inpp5k as a novel axon growth activator that enhances sprouting of corticospinal tract axons after CNS trauma by increasing cofilin activity and actin polymerization.

This study identifies midbrain-derived glial factors upregulated after hemispherectomy that promote ectopic cortico-mesencephalic axonal projections.

This study compares vascularized and non-vascularized nerve grafts in animal models, finding better nerve recovery in vascularized grafts but with some results being sensitive to analysis.

The paper shows that Schwann cell loss causes demyelination and transcriptional reprogramming in specific sensory neurons, suggesting a non-cell autonomous response to axon-Schwann cell interaction loss.

This paper applies optical tissue clearing to study nerve regeneration in rats, enabling 3D morphological analysis of nerves and their targets with high precision and speed.

This study shows that knocking out pten in mature spinal motor neurons enhances axonal regeneration and synaptic reconnection after spinal cord injury.

This study shows that Transthyretin (TTR) promotes axon growth by regulating microtubule dynamics and tubulin acetylation, with restoration of acetylated tubulin rescuing defects in TTR knockout mice.

This study shows that retinoic acid treatment increases macrophage numbers and phagocytic activity, which enhances axonal regeneration after optic nerve injury in frogs.

This study identifies compounds that promote axon regeneration using human iPSC-derived motor neurons and validates blebbistatin as a top hit in vivo.

This paper develops a biodegradable nerve wrap that locally delivers tacrolimus to promote axonal regeneration and functional recovery with reduced systemic drug exposure.

This paper describes a novel experimental model for double nerve transfers to a single target muscle in rats, showing successful reinnervation without functional deficits.

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

This study compares the DRG microenvironment's response to peripheral and central axon injuries using single-cell profiling, identifying PPAR pathway activation in satellite glial cells as critical for peripheral regeneration.

This study identifies FKBPL and FKBP8 as proteins that regulate DLK stability and degradation, affecting neuronal responses to axon injury but not regeneration.

The paper identifies nicotinic acid mononucleotide (NaMN) as an allosteric inhibitor of SARM1 that promotes axonal protection by blocking NMN binding and stabilizing the inactive SARM1 conformation.

This study shows that overexpressing RTN3 promotes axon regeneration and functional recovery after CNS injury, dependent on protrudin.

This study shows caldendrin inhibits neurite regeneration in dorsal root ganglion neurons, with a sex-dependent effect on Cav1 channel regulation.

The paper identifies chromatin accessible sites and transcription factors in RGCs that correlate with axon growth capacity and shows CREB overexpression promotes axon regeneration.

This study identifies CED-10 and TIAM-1 as critical regulators of dendrite regeneration in C. elegans PVD neurons, distinct from axon regeneration pathways.

This study shows that astrocytes switch from a kinase-based to a calcium-based response to BDNF during development, with Kidins220/ARMS modulating both pathways and regulating Kir4.1 expression.

This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.

This paper develops a novel scaffold biomaterial coated with extracellular matrix proteins to promote axonal regeneration after spinal cord injury.

This study shows ALKBH1 demethylates N6-mA in sensory neurons, promoting axon regeneration by regulating neurodevelopmental genes.

This study examines how associative learning and escitalopram affect serum BDNF levels in healthy humans, finding significant time effects during learning and a negative correlation between citalopram and sBDNF levels.

The paper uses quantitative proteomic analysis to identify guidance molecules and associated factors in the adult visual system, revealing their potential role in axon guidance during CNS regeneration.

The paper shows that prenyl-Cdc42 mRNA localizes to PNS axons and promotes axon growth through localized translation and prenylation.

This study identifies Pax3 as a key factor in promoting directed axon outgrowth and correct targeting during neural circuit repair in response to BDNF.

The paper identifies a non-coding function of the injury-responsive gene Gpr151 that promotes axon regeneration through its 5UTR interacting with RNA-binding proteins.