Nerve injury and regeneration

This study shows that the prion protein is not required for sciatic nerve regeneration after crush injury in mice.

The paper shows that restoring Schwann cell c-Jun rescues nerve regeneration failures in aging and chronic denervation by enhancing regenerative support.

This study shows that Celsr2 negatively regulates motor axon regeneration in mice and humans, with its knockdown promoting axon regeneration and functional recovery.

This study shows that spinal cord injury (SCI) in dorsal column sensory neurons leads to downregulation of lipid metabolism genes, unlike sciatic nerve injury, which may hinder axon regeneration.

This study identifies efferocytosis as a key mechanism for nerve debridement following sciatic nerve injury through single-cell RNA-sequencing and genetic analysis.

This study identifies GSK-3β and Smad3 as key mediators of TGF-β1's anti-neuritogenic effects by modulating CRMP2 phosphorylation in sensory neurons.

The paper proposes using adult retina explants as an ex vivo model to study axon regeneration in the mature CNS, offering advantages over in vitro and in vivo approaches.

This study identifies mechanisms explaining why DLK couples to JNK3 rather than other MAPKs, showing JNK3 palmitoylation facilitates pro-degenerative axon-to-soma signaling.

This study shows that ZDHHC17 couples DLK and NMNAT2 pathways to control both somal and distal axon degeneration after optic nerve crush.

This study shows OTX2 promotes both survival and axon regeneration of adult retinal ganglion cells in vitro and in vivo.

This study uses optogenetics to activate ERK and AKT signaling in Drosophila, enhancing axon regeneration and functional recovery in both PNS and CNS.

This study identifies fatty acid synthesis in satellite glial cells as a mechanism promoting axon regeneration after nerve injury.

This study identifies rab-27 in C. elegans intestines as a regulator that inhibits axon regeneration through a neuropeptide secretion pathway.

The paper shows that peripheral sensory neurons undergo consistent transcriptional changes after axonal injury, which promote regeneration but also suppress cell identity, with Atf3 playing a key role.

This study shows that inhibiting PTEN promotes axon regeneration in adult sensory neurons, particularly in IB4-positive neurons following peripheral axotomy.

This study shows that inducing collateral sprouting in uninjured sensory neurons in vivo primes them for enhanced axon outgrowth in vitro without axonal injury.

The paper identifies ERK1/2 and other pathways as novel components of Nogo-A signaling that mediate long-term neurite outgrowth inhibition.

The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.

The paper identifies novel transcription factor synergies that enhance axon growth by analyzing co-occupancy patterns and validating them through experimental screens and animal models.

The paper shows that prenylation of axonally translated proteins is required for NGF-dependent axon growth in sympathetic neurons.

This study shows YAP/TAZ are necessary for Schwann cell remyelination but not proliferation after nerve injury, and their expression depends on axon regeneration.

This study investigates the role of integrin-linked kinase (ILK) in Nogo-66-induced inhibition of neurite outgrowth, showing ILK regulates downstream signaling and promotes neurite growth.

This study shows that knocking out myosin IIA/B in retinal ganglion cells promotes optic nerve regeneration, with synergistic effects when combined with Lin28 overexpression.

This study identifies FL2 as a negative regulator of axonal growth and shows that targeting it with siRNA promotes nerve regeneration in a rodent model of peripheral nerve injury.

This paper describes a porcine model for studying long-distance peripheral nerve regeneration, focusing on surgical techniques and outcomes for ultra-long regenerative distances.

This paper describes a mouse line with inducible Cre expression specifically targeting Remak Schwann cells, with partial neuronal depletion using Flpe.

This study shows that Protrudin, when overexpressed, supports axon regeneration in the adult central nervous system by acting as a scaffold to organize endoplasmic reticulum, integrins, and Rab11 endosomes in the distal axon.

The paper identifies Robo2 as a key regulator of target-selective peripheral nerve regeneration in response to glia-derived signals in zebrafish.

This study shows UNC-16/JIP3 inhibits axonal regeneration by regulating DLK-1 function, affecting actin and microtubule dynamics differently depending on DLK-1 involvement.