Salmonella and Campylobacter epidemiology

Whole genome-based Characterization of Virulence and Antimicrobial Resistance Determinants in Clinical Campylobacter jejuni Isolates from Minnesota, 2018-2021

This study uses whole-genome sequencing to analyze virulence and antimicrobial resistance in 2,783 Campylobacter jejuni isolates, finding high prevalence of resistance genes and strong correlation between genotypic and phenotypic resistance profiles.

The Salmonella effector SspH2 disrupts F-actin cytoskeletal organization to inhibit macrophage migration

This study shows that SspH2, an effector of Salmonella, inhibits macrophage migration by disrupting F-actin cytoskeletal organization through E3 ligase activity and vinculin interactions.

Human-targeted drugs impact antibiotic sensitivity and growth of Campylobacter jejuni

This study shows that human-targeted drugs can both enhance antibiotic resistance and inhibit Campylobacter jejuni growth through efflux pump activation and direct toxicity.

Integrative Genomic and Structure-Based Prioritization of Molecular Targets in Multidrug-Resistant Salmonella enterica from Brazilian Poultry

This study identifies molecular targets in multidrug-resistant Salmonella isolates from poultry using genomic and structural analysis, highlighting AcrB as a promising target.

Microbiota-derived indole limits Campylobacter jejuni colonization by inhibiting respiration and metabolism

This study shows that microbiota-derived indole inhibits Campylobacter jejuni colonization by disrupting its respiration and metabolism in an inflamed gut.

Hepatic Transcriptomic Landscape of Chicken Reveals Host Responses to Spotty Liver Disease

This study identifies differentially expressed genes and pathway alterations in chickens with Spotty Liver Disease, revealing immune activation and metabolic suppression.

The broad ecological range of Salmonella enterica serotype Typhimurium is associated with genomic diversification

This study analyzes 595 Salmonella Typhimurium genomes to show that food animal isolates have more open pangenomes and antimicrobial resistance genes, with swine isolates showing the most diversity and plasmid prevalence.

Campylobacter jejuni Infection Is Associated With Cell-Cycle, Redox, and Metabolic Remodeling of Human Intestinal Epithelial Cells at Single-Cell Resolution

This study uses single-cell RNA sequencing to show that C. jejuni infection alters cell-cycle, redox, and metabolic states in human intestinal epithelial cells.

Host breadth, genomic exchange and antimicrobial-resistance evolution in East African Campylobacter

This study analyzes genomic data from Campylobacter species in East Africa to investigate host breadth and antimicrobial resistance, finding no strong associations with genome exchange or resistance burden.

Type 2 diabetes increases susceptibility to invasive Salmonella Typhimurium despite butyrate supplementation

This study shows that type 2 diabetes increases susceptibility to invasive Salmonella Typhimurium infection despite butyrate supplementation, highlighting a link between hyperglycemia and altered gut microbiota.

Evaluation of Oxford Nanopore Sequencing for Antimicrobial Resistance Surveillance in Salmonella: Comparison with Phenotypic Antimicrobial Susceptibility in a Large-Scale Study

This study evaluates Oxford Nanopore sequencing for AMR detection in Salmonella, comparing it to phenotypic testing and finding high concordance but notable discrepancies in resistance classification.

Identification of genes promoting fitness of a plant-associated Salmonella Choleraesuis strain on alfalfa sprouts during cold storage

This study identifies genes promoting the persistence of a plant-associated Salmonella Choleraesuis strain on alfalfa sprouts during cold storage through transposon mutagenesis and competition experiments.

Efficient colonic colonization by Campylobacter jejuni requires the heme receptor ChuA

This study shows that the heme receptor ChuA is essential for Campylobacter jejuni to efficiently colonize the colon and cause inflammation.

Multilevel HierCC typing scheme for global genomic epidemiology and antimicrobial resistance surveillance of Campylobacter jejuni

This paper develops a multilevel HierCC typing scheme for global C. jejuni AMR surveillance and epidemiology, identifying resistant clusters and host-specific patterns.

African Campylobacter jejuni genomes reveal globally connected population structure and regionally variable resistance, virulence and mobilome profiles

This study analyzes 1,013 Campylobacter jejuni genomes to show African diversity is globally connected and regionally variable in resistance, virulence, and mobilome profiles.

Provision of Preferred Nutrients to Macrophages Enables Salmonella to Replicate Intracellularly Without Relying on Type III Secretion Systems

This study shows Salmonella can replicate in macrophages without Type III Secretion Systems if provided with preferred nutrients, highlighting the role of host metabolic heterogeneity in bacterial replication.

Multimodal temporal mapping of macrophage transcriptome remodeling during Salmonella infection

The paper uses temporal single-cell RNA-seq and other methods to study how Salmonella rewires macrophage gene expression and transcription factor activity during infection.

Development and Evaluation of a PCR Test System for the Detection of Salmonella spp. in Clinical and Epidemiological Materials

This paper develops and evaluates a TaqMan real-time PCR assay targeting the hilA gene for detecting Salmonella spp. in clinical and food samples, showing high sensitivity, specificity, and broad serovar coverage.

Incremental AMR acquisition driving successive genotype replacements and the rise of extensively drug resistant (XDR) Shigella sonnei in Australia over 20 years.

This study tracks the rise of extensively drug-resistant Shigella sonnei in Australia over 20 years, linking genotype changes to antimicrobial resistance and public health threats.

Human-restricted Salmonella exploit preassembled flagella for intracellular motility and vacuolar escape

This study shows human-restricted Salmonella retain preassembled flagella during host cell invasion, using them for intracellular motility and vacuolar escape, while non-typhoidal Salmonella do not.

Engineering a Hyper-Adherent E. coli Nissle Probiotic Strain that Reduces Intestinal Carriage of SalmonellaPathogens in Poultry

This paper engineers an E. coli Nissle probiotic strain expressing Salmonella type 1 fimbriae to reduce Salmonella carriage in poultry.

Genome-scale dissection of phase-variable gene function in Campylobacter jejuni using a stabilized phasotype library

This paper introduces PV-GenShift, a platform to stabilize phase-variable gene expression in C. jejuni, identifying phasotypes linked to serum resistance and mouse colonization.

Salmonella Genomic Markers for Risk to Food Safety

The paper identifies genomic markers in Salmonella isolates that correlate with infection risk, showing lineage-specific associations and a conserved prophage marker in Salmonella Agona.

Flagellar system translocates T3SS effectors critical for Salmonella infection

This study shows that Salmonella's flagellar T3SS translocates T3SS effectors into host cells, a process critical for infection and independent of the later-induced injectisome.

Genetic and epigenetic diversity of Salmonella enterica isolates from Kazakhstan from clinical and veterinary sources

This study analyzes the genomic and epigenetic diversity of Salmonella enterica isolates from Kazakhstan, identifying distinct genetic clusters and epigenetic modifications linked to virulence and antibiotic resistance.

Development and validation of a genome-informed multiplex PCR for specific detection of typhoidal Salmonella serovars

The paper develops and validates a genomics-informed multiplex PCR assay to specifically detect typhoidal Salmonella serovars, achieving high specificity and sensitivity.

Novel pESI-encoded autotransporter adhesin PeaP of epidemic Salmonella strains mediates adhesion, atypical biofilm formation, and poultry colonization

This study identifies PeaP, a novel pESI-encoded adhesin in Salmonella Infantis that enables temperature-tolerant biofilm formation and poultry colonization.

Clinical Campylobacter jejuni isolates: genomes and genetic tools

The paper sequences two Campylobacter jejuni strains and develops a plasmid system to enhance genetic tools for studying clinical isolates.

A bare host cell membrane with minimal glycocalyx is an optimal surface for targeting by virulence-primed Salmonella Typhimurium

This study identifies that a minimal glycocalyx on host cell membranes optimally facilitates Salmonella Typhimurium targeting, with glycoproteins and cholesterol playing key roles.

WISH-barcoding of Salmonella Typhimurium ATCC14028s strains for population dynamics studies in vivo

The paper evaluates WISH-barcoding in Salmonella Typhimurium for in vivo population dynamics, finding wild-type strains prone to fitness-altering mutations during in vitro construction.