Folate and B Vitamins Research

This study shows catalpol reduces HHcy-induced endothelial dysfunction by inhibiting EndMT through the ROS/NF-κB pathway in both in vitro and in vivo models.

This study shows that folate improves cognitive function in elderly mice by partially rejuvenating dentate gyrus cells through FR activation and increased expression of juvenile genes.

The paper investigates how vitamin B12 and folic acid affect mitochondrial DNA heteroplasmy in mice and suggests potential sex-specific effects in humans.

This study identifies TET1 as a key mediator of gene-environment interactions in congenital malformations, showing how maternal folate status and genetic background influence DNA methylation and NTD susceptibility.

This study shows folate depletion induces erythroid differentiation by disrupting purine synthesis, with effects mimicked by SHIN1 inhibition and rescued by purine precursor supplementation.

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

This study shows that folate depletion in culture medium alters mouse trophoblast stem cell differentiation and endoreduplication.

This study uses zebrafish tcn2 knockout to investigate B12's role in embryonic development, finding that B12 supplementation partially rescues developmental defects and alters gene expression in key pathways.

This study identifies a non-canonical role of folate and FOLR1 in neural tube formation through regulation of CD2AP and Ca2+ signaling, distinct from its metabolic function.

This study examines how maternal dietary deficiencies in one-carbon metabolism affect ischemic stroke outcomes in middle-aged offspring, finding reduced neurodegeneration and neuroinflammation but no impact on motor function.

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.

This study examines how maternal deficiencies in folic acid or choline affect cerebral and peripheral blood flow in female mouse offspring after ischemic stroke.

This study shows that disrupted folate metabolism in mice causes conceptus misalignment and developmental issues across generations, independent of maternal uterine factors.

This study examines the effects of dietary folic acid deficiency on hippocampal morphology and cortical acetylcholine metabolism in male and female mice, finding sex differences in hippocampal apoptosis but not in morphology or acetylcholine levels.

The paper analyzes the associations of MTHFR SNPs 677C/T and 1298A/C with breast cancer risk in a South-Asian population, finding significant diplotype effects but no independent SNP associations.

This study uses Mendelian Randomization to assess the causal effect of maternal vitamin B12 and folate on offspring birthweight, finding a positive causal effect for folate but not for B12.

The paper identifies two mechanisms by which vitamin B12 regulates the methionine/S-adenosylmethionine cycle in C. elegans, involving transcriptional adjustments via nuclear hormone receptors.

This study examines how folic acid deficiency and supplementation affect mutation rates in bone marrow and colon, revealing tissue-specific mutagenic effects.

This paper uses Mendelian randomisation to investigate the causal relationship between genetically predicted serum folate levels and cancer risk, finding little evidence of a causal association.

This study investigates how MTHFR deficiency in mice affects cellular responses after ischemic stroke, finding increased antioxidant activity and altered MAT2A and HIF-1 levels.

This study shows vitamin B12 reduces hippocampal apoptosis and inflammation in a rat model of bacterial meningitis by modulating DNA methylation and homocysteine levels.

A meta-analysis of ten case-control studies found no significant association between MTHFR A1298C polymorphism and Alzheimer's disease risk across most genetic models.

This study investigates how different doses of natural folate or synthetic folic acid affect neurogenesis, homocysteine, and corticosterone in adult female rats.

This paper assesses how the MTHFR SNP rs1801133 affects plasma homocysteine levels, considering covariates like folic acid intake, and finds significant variability due to effect modification and confounding.