Cancer-related molecular mechanisms research

The paper identifies novel lncRNA-mediated networks dysregulated in ALS by analyzing single-nucleus RNA-seq data from human brain cortex.

SCancerRNA is a database that compiles single-cell expression data and interaction networks of non-coding RNA biomarkers for cancer diagnosis and therapy.

The paper identifies ASAR lncRNAs as regulators of DNA replication timing through interactions with hnRNP proteins, showing their role in chromosome stability and replication synchronization.

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

The paper develops a machine learning model to identify functional lncRNAs and validates SNHG6's role in hematopoietic differentiation and leukemia.

This study identifies GAS6-AS1 as a key regulator of 5-FU resistance in CRC by stabilizing MCM3 mRNA through PCBP1 recruitment, suggesting it as a therapeutic target.

The paper introduces TransCistor, a framework to identify cis-regulatory lncRNAs with controlled false discovery rates, finding that only a minority of lncRNAs are cis-acting, primarily as activators.

This study identifies and characterizes 91,209 lncRNAs in Cucurbitaceae using RNA-seq data, highlighting their tissue-specific and stress-responsive expression patterns.

The paper shows that transcription inhibition in cancer cells leads to the generation of DoGs, suggesting they are part of a cellular stress response.

The paper defines the full-length transcriptome of primary and metastatic liver cancers and identifies isoform-level diversity and metastasis-specific transcripts with clinical implications.

The paper identifies SRS-lncRNAs expressed during neuronal differentiation and shows their potential to interact with RNA-binding proteins.

The paper maps Ppp1r1b-lncRNA chromatin occupancy genome-wide in mouse muscle myoblasts using ChIRP-seq, identifying binding sites enriched for myogenic regulators and enhancers.

The paper identifies PSG8-AS1 as an oligodendrocyte-specific long non-coding RNA with potential diagnostic and prognostic value in oligodendroglioma.

The paper maps lncRNA landscapes across ten cancer types using single-nucleus RNA sequencing and identifies cell type-specific lncRNA-mRNA pairs and regulatory networks.

This study identifies 20 human lncRNA-encoding genes with potential orthologs in plant genomes, including 3 linked to cancer-related lncRNAs in databases.

This paper introduces SCOM, a framework to identify ncRNA synergistic competition across cancers, revealing hub ncRNAs and potential biomarkers for diagnosis and prognosis.

The paper identifies three lncRNAs that interact with prostate cancer and androgen receptor-targeted proteins and suggests SCARNA10 as a prognostic signature for prostate cancer.

The paper develops an EMT-related lncRNA prognostic signature and classification system for lung squamous cell carcinoma, identifying key genes and subtypes with distinct prognostic and immunotherapy profiles.

The paper constructs a ceRNA network in esophageal cancer and identifies SYT10 as a potential prognostic biomarker based on survival analysis of differentially expressed RNAs.

The paper introduces linc2function, a deep learning model that identifies and functionally annotates long noncoding RNAs using sequence, structure, and interactome features across species.

This study examines how SNPs in lncRNAs affect their secondary structure and RNA binding protein interactions, potentially contributing to disease.

The paper identifies functionally conserved non-homologous lncRNAs across species using k-mer content and structural analysis, validated through CRISPR Display in human and chicken cells.

The paper identifies a structured protein interaction hub in the long non-coding RNA NORAD using biochemical and sequencing methods.

This study shows that LINC00941 interacts with the NuRD complex to regulate epigenetic occupancy and suppress premature human epidermal differentiation.

This study shows that TRG-AS1 promotes colorectal cancer growth by regulating P2RY10 and GNA13 expression, as demonstrated through in vitro and in vivo experiments.

This study identifies HOXDeRNA as a long non-coding RNA that derepresses glioma-specific transcription factors by interacting with PRC2 and RNA quadruplex structures, driving astrocyte transformation into glioma-like cells.

This study identifies LINC01117 as a regulator of EMT in lung adenocarcinoma, showing its role in promoting cell migration and invasion through modulation of EMT markers.

This study identifies GRAS1 lncRNA as a protector against DNA damage and cell death by stabilizing NKAP protein.

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

BCLncRDB is a database of breast cancer-associated lncRNAs containing 5,279 associations with features like expression, methylation, and drug information.