Phillip A. Yates

The paper identifies and characterizes Autosomal Inactivation/Stability Centers (I/SCs) as loci with allele-specific epigenetic regulation of replication timing and gene expression, showing dosage sensitivity and implications for human diseases.

The paper introduces a CRISPR/Cas9-based protein tagging system for Kinetoplastids that preserves endogenous regulatory elements and demonstrates its utility in studying gene regulation.

The paper identifies ASAR lncRNAs as regulators of DNA replication timing through interactions with hnRNP proteins, showing their role in chromosome stability and replication synchronization.

The paper identifies hundreds of epigenetically controlled long noncoding RNA genes essential for chromosome replication and stability, validating their role in chromosomal integrity.

The paper identifies distinct cis-acting elements regulating purine-responsive gene expression in Leishmania donovani, specifically for LdNT1 and LdNT2.

The paper identifies a conserved RNA stem-loop in the LdNT3 mRNA 3' UTR that mediates purine-responsive upregulation in Leishmania donovani, with species-specific functionality due to variant bases.