Corneal surgery and disorders

Reinterpreting Keratoconus Gene Expression in Light of Inherited Stromal Weakness

This paper reinterprets keratoconus gene expression by showing that expression direction depends on control choice and stromal state, not disease causation or intervention effectiveness.

Differential expression of NEAT1 in the corneal endothelium increases susceptibility to oxidative stress in Fuchs Endothelial Corneal Dystrophy

This study identifies reduced NEAT1 expression in the central corneal endothelium as a factor increasing susceptibility to oxidative stress in Fuchs Endothelial Corneal Dystrophy.

Genome-wide association study of corneal dystrophy uncovers novel risk loci and enables improved polygenic prediction of Fuchs endothelial corneal dystrophy

This paper identifies 24 risk loci for corneal dystrophy, constructs polygenic risk scores (PRS) and STR-based models, and shows PRS improves FECD prediction, while STR expansion is the strongest predictor.

Ferritinophagy Contributes to Iron Accumulation and Ferroptosis in FuchsEndothelial Corneal Dystrophy

This study shows ferritinophagy contributes to iron accumulation and ferroptosis in FECD, with UVA exposure activating this process.

Interplay between ferroptosis and guttae in an early-onset murine model of Fuchs endothelial corneal dystrophy (FECD)

This study shows that ferroptosis is linked to guttae formation in a murine model of Fuchs endothelial corneal dystrophy, providing a model for testing ferroptosis-targeted therapies.

Integration of mechanical testing, in vivo optical coherence elastography and personalized finite element modeling to predict geometrical outcomes of corneal cross-linking

This paper predicts corneal topographic changes after cross-linking using finite element models calibrated with mechanical tests and in vivo optical coherence elastography.

Characterization of the SKC mouse strain as a potential model for keratoconus

This study examines SKC mice to identify corneal phenotypes related to keratoconus, finding lower penetrance and male-specific abnormalities.

TAZ (Wwtr1) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs' endothelial corneal dystrophy

This paper investigates TAZ deficiency in a mouse model of FECD, identifying ER stress, mitochondrial dysfunction, and altered ECM organization as key pathogenic mechanisms.

Integrated monogenic and polygenic risk predicts disease progression in Fuchs endothelial corneal dystrophy

This study combines monogenic and polygenic risk factors to predict disease progression in Fuchs endothelial corneal dystrophy, showing improved prediction when integrating both factors.

Epigallocatechin Gallate (EGCG) as a Protective Agent Against Enzymatic Stromal Degradation in Caprine and Ovine Corneas: Towards Novel Therapeutics for Keratoconus

This study evaluates EGCG's protective effects against enzymatic stromal degradation in goat and sheep corneas and validates these animals as ex vivo models for keratoconus research.

Oxidative-stress related increase in keratoconus tear MDA and GPX3 while NRF2-antioxidant functions decrease in stromal cells

This study identifies increased MDA and GPX3 in KC tears and NRF2 dysfunction in stromal cells, suggesting potential biomarkers and therapeutic targets for keratoconus.

Decreased substrate stiffness leads to mitochondrial dysfunctions and Endothelial to Mesenchymal transition through Focal Adhesion Kinase activity in corneal endothelial cells

This study investigates how reduced substrate stiffness affects corneal endothelial cell health, finding increased FAK activity and EndMT, but no improvement in disease progression with FAK inhibition.

Proteasomal Dysfunction results in ER stress, Endo MT, oxidative stress, and apoptotic cell death resulting in Fuchs Corneal Endothelial Dystrophy like features in mice

This study shows proteasomal dysfunction causes ER stress, endo-mesenchymal transition, oxidative stress, and apoptosis in mice, leading to FECD-like features.

Intrastromal graft of anterior lens capsule. A substitute for Bowman layer graft transplantation for keratoconus.

This study evaluates the use of anterior lens capsule as a graft substitute for Bowman layer in keratoconus treatment, showing preservation of corneal transparency and structure in a rabbit model.

A unique and biocompatible approach for corneal collagen crosslinking in vivo

This study evaluates a novel corneal crosslinking method using ruthenium and blue light in rats, showing rapid epithelial healing and no corneal opacity by day 6.

A safe and effective method for thin cornea cross-linking

This paper introduces a new corneal cross-linking method using photo-initiators and visible blue light, which is safer and more effective for thin corneas than the standard riboflavin/UVA protocol.

Zebrafish carbohydrate sulfotransferase 6 (chst6) mutants provide a preclinical model for macular corneal dystrophy

This paper develops a zebrafish model of macular corneal dystrophy by knocking out the chst6 gene, showing age-dependent corneal abnormalities and structural defects.

Tyr is Responsible for the Cctq1a QTL and Links Developmental Environment to Central Corneal Thickness Determination

The paper identifies Tyr as the gene responsible for the Cctq1a QTL and shows that developmental light exposure interacts with genotype to influence central corneal thickness.

A Mouse Model of Brittle Cornea Syndrome caused by mutation in Zfp469.

This paper creates a mouse model of Brittle Cornea Syndrome to study the molecular mechanisms of corneal thinning and its pathogenic effects.

Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy

The paper identifies aberrant DNA methylation of miRNA genes, particularly miR-199B, in Fuchs endothelial corneal dystrophy, linking it to dysregulated extracellular matrix production through miR-199b-5p suppression of Snai1 and ZEB1.

Quantification of double stranded DNA breaks and telomere length as proxies for corneal damage and replicative stress in 64 human keratoconus corneasThe role of DNA damage in the development of keratoconus

This study quantifies DNA damage and telomere length in keratoconus corneas to assess oxidative stress and replicative stress, finding no significant DNA damage differences but longer telomeres in keratoconus.

Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-affected Corneas

The paper identifies differentially expressed coding and long noncoding RNAs in keratoconus-affected corneas and finds enriched pathways and correlations suggesting their functional roles.

mTOR complex 1 pathway activation in severe keratoconus; the functional implications of GWAS identified loci.

The paper identifies up-regulation of the mTORC1 pathway in keratoconus corneas and confirms differential expression of GWAS risk loci.