Samuel Herberg

The paper identifies 588 differentially expressed genes in glaucomatous versus normal trabecular meshwork cells cultured in a soft ECM environment, revealing three disease-related programs.

This study provides a comprehensive multiomic analysis of non-glaucomatous human trabecular meshwork cells using data from multiple laboratories.

This study investigates how reduced substrate stiffness affects corneal endothelial cell health, finding increased FAK activity and EndMT, but no improvement in disease progression with FAK inhibition.

TGFβ2 raises TRPV4 expression and activity in human trabecular meshwork cells; TRPV4 blockade or deletion lowers TGFβ2-driven ocular hypertension and contractility in mice and hydrogels.

This study investigates how compressive strain affects astrocyte morphology, metabolism, and ECM modification in a 3D hydrogel model of the optic nerve head.

This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.