Neurogenesis and neuroplasticity mechanisms

The paper shows that oligodendrocytes selectively myelinate Purkinje cell axons in the mouse cerebellar white matter, with this preference established during development.

The paper identifies a novel subset of cerebellar nuclei neurons in mice that originate from an extrinsic germinal zone, distinct from the rhombic lip and ventricular zone.

The paper identifies NEUROG2's role in regulating a human-specific gene regulatory program in neural progenitor cells through transcriptomic analysis of knock-in organoids.

This study identifies Her9's role in maintaining hindbrain boundary cells as proliferative progenitors by inhibiting neurogenesis and promoting symmetric divisions.

The paper develops human MGE-pINs from pluripotent stem cells and shows their maturation into SST and PVALB subtypes with functional and molecular characteristics.

This study shows KIF3C is essential for cerebellar development through regulating Bergmann glia density and patterning, independent of Hedgehog signaling.

This study uses a morphogen screen in human neural organoids to generate diverse neural cell types and uncover design principles of brain region specification.

The paper identifies Nup153 as the anchor for Kif1a during G1-phase basal nuclear migration in radial glial progenitor cells, completing the model for interkinetic nuclear migration.

This study identifies P2Y13 as a key regulator of NSC activation and division mode in the adult SEZ, distinguishing quiescent from activated NSCs and influencing self-renewal versus differentiation.

The paper identifies four V1 interneuron clades in the spinal cord based on birthdate, lineage, and connectivity, showing functional differences in their synaptic connections and circuit roles.

This study examines the role of MYT1L in neuronal development by analyzing gene expression in wild-type and MYT1L-deficient mice, finding disruptions in excitatory neuron proportions and gene expression.

The paper investigates embryonically generated interneurons in the mouse olfactory bulb, showing their distribution, developmental timing, and distinct lamination patterns.

The paper identifies an immature neuroblast population with plasticity and molecular switches in splicing regulators during neurogenesis.

This study identifies a compound that enhances adult hippocampal neurogenesis and improves behavioral pattern separation in both young and aged mice.

This study shows Marcks and Marcksl1 proteins are essential for spinal cord development and regeneration in Xenopus, with some functions mediated by PLD signaling.

This paper identifies leucovorin and dyclonine as pro-oligodendrogenic compounds through pharmacogenomic screening and validates their therapeutic potential in mouse models of myelin pathologies.

The paper shows that nuclear shape changes and packing order during neurogenesis are critical for retinal lamination in zebrafish.

This study shows that adult hippocampal NSPCs secrete VEGF, which supports and protects hippocampal function independently of neurogenesis.

This study shows how a single neural stem cell type generates segment-specific lineages by producing different temporal cohorts through variations in division patterns and post-mitotic mechanisms.

The paper presents a 3D digital atlas of the human fetal brain at 21 weeks gestation, revealing molecular signatures of cortical expansion linked to neurogenesis timing and evolutionary boundaries.

This study shows that Cspg4 regulates oligodendrocyte precursor cell morphology in zebrafish without affecting myelin sheath production.

This study shows FGF8 signaling influences regional identity and cellular diversity in human cerebral organoids, affecting neural progenitor fate and genes linked to neurodevelopmental disorders.

The paper shows IL-17A disrupts human cortical development in a 3D ex vivo model of maternal immune activation by altering neurogenesis and ECM pathways.

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

This study investigates the role of Serpina3n in postnatal brain development and myelination, finding it dispensable under homeostatic conditions but involved in oxidative stress responses.

This study shows Olduvai domains suppress mitochondrial pathways, delaying cellular maturation and promoting brain size increase in humans.

This study identifies SOX4, SOX11, and TFAP2D as critical regulators of ventropallial excitatory neuron development and PFC connectivity in mice, with conserved roles in humans.

This study identifies RSPO/LGR signaling as a mechanism by which astrocytes regulate proliferation of adult hippocampal neural stem cells through Wnt signaling.