René Hen

This paper performs two meta-analyses of transcriptional data from rodent brain regions to identify shared gene expression changes across antidepressant categories.

This paper introduces a new optical framework and imaging devices that enable scalable, high-resolution, multi-immersion light-sheet microscopy for biological samples.

This study shows ECS-induced neurogenesis is necessary for antidepressant effects and identifies transcriptomic changes in granule neurons.

This study shows psilocybin activates hypothalamic stress-related neurons, with stronger effects in female mice and context-dependent changes in threat assessment.

The paper examines how different cell types in the ventral hippocampus encode anxiety-related information during an anxiety test, finding distinct encoding patterns in granule cells and mossy cells.

This study investigates how input compressibility affects optimal sparsity in sparse autoencoders, finding that optimal coding levels depend on memory demand and input statistics.

This study shows that fluoxetine reactivates a dormant developmental plasticity program in mature neurons, leading to synaptic rejuvenation and antidepressant-like effects.

This study identifies a compound that enhances adult hippocampal neurogenesis and improves behavioral pattern separation in both young and aged mice.

This study identifies population codes in ventral CA1 neurons that represent anxiety-related environmental features and moment-to-moment anxiety states in mice.

This study investigates how adult born granule cells influence pattern separation by modulating remapping of place and cue cells in the hippocampus.

The paper identifies 'cue cells' in the dentate gyrus that encode sensory cues independently of spatial location, alongside traditional 'place cells', revealing a previously overlooked heterogeneity in DG function.

This study investigates how increased adult hippocampal neurogenesis affects stress-related behavior and brain network connectivity in mice exposed to chronic stress.

The paper shows that position, direction, and speed in the hippocampus are encoded by overlapping neuronal ensembles in dentate gyrus and CA1, suggesting a distributed neural code rather than single-cell specialization.

The paper shows that doublecortin (DCX) expression does not linearly correlate with adult hippocampal neurogenesis (AHN) in various models, highlighting the need for caution in using DCX as a proxy for AHN.

This study investigates the effects of the depression-related SNP rs6295 on 5-HT1A receptor levels and behavior using humanized mouse models.

This study uses optogenetic silencing to show that both mature and immature neurons in the dentate gyrus contribute to memory discrimination, with distinct effects based on prior experience.