Neurogenesis and neuroplasticity mechanisms

The paper identifies developmental molecular programs that control the emergence and area-specific distribution of two subtypes of cortical motor projection neurons.

This study differentiates human hindbrain neuroepithelial stem cells into cerebellar granule neurons in vitro, recapitulating key progenitor states and showing SHH's role in lineage specification and maturation.

This study shows that intermittent hypoxia therapy increases gliogenesis and neuroblast migration in a rat MCAO stroke model.

This study shows that Shh/Smo activation maintains oligodendrocyte precursor cells (OPCs) in an undifferentiated state but is not required for myelination or remyelination.

This study shows that serine racemase (SR) influences adult subventricular zone (SVZ) neurogenesis by regulating fatty acid synthesis and lipid metabolism.

The paper uses genetic fate mapping in mice to show how direct and indirect neurogenesis contribute differently to the diversity and connectivity of glutamatergic projection neurons in the cerebral cortex.

The paper uses lineage tracing in human cortical organoids to show that most neurons arise from intermediate progenitors and that genetic variants affect lineage-specific transcriptional profiles and neuron diversity.

The paper shows that FoxJ1+ Pax6+ Sox2+ ependymal cells persist in the human spinal cord throughout life, maintaining neurodevelopmental gene expression and structural features similar to those in mice and young humans.

This study shows that Amyloid Precursor Protein (APP) is required for human neural stem cells to maintain a progenitor state during prolonged neurogenesis, unlike mouse NSCs where APP is dispensable.

The paper identifies a gene regulatory network involved in multiciliation that is repurposed in the fate specification of Cajal-Retzius neurons, leading to distinct cellular outcomes.

The paper shows that astrocyte-oligodendrocyte interaction is critical for remyelination and identifies a drug strategy targeting this interaction to promote central nervous system regeneration.

The paper identifies an expanded subventricular zone in neonatal gyrencephalic brains that supports ongoing neuronal migration to the cortex.

The paper shows neuron densities in mammalian cerebral cortex follow a lognormal distribution across and within cortical areas, suggesting a new organizational principle.

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

The paper uses live imaging to show that retinal progenitors make both deterministic and probabilistic fate decisions, with stochasticity increasing under developmental stress.

This study develops a DNA-based modulator to replace growth factors in culturing human neural progenitor cells, enabling long-term propagation and neurogenesis.

This study shows that targeting TGF-alpha release rescues neurogenesis and cognitive decline in SAMP8 mice, suggesting it as a potential therapeutic strategy for age-related neurological disorders.

This study shows Notch signaling regulates miRNA levels to control neuron fate determination and telencephalic development.

This study shows Pgbd5 is essential for neuronal differentiation and radial migration in mouse corticogenesis, with effects on DNA double-strand breaks and gene expression.

This study shows EIF4A3 controls mitosis duration and cell survival in mouse and human neural progenitors, linking it to neurodevelopmental disorders.

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.

This study shows autophagy is essential for establishing quiescence in hippocampal neural stem cells during development.

The paper shows Dbx1-expressing progenitors in the olfactory epithelium contribute to multiple neuronal lineages, revealing unexpected diversity in their neurogenic potential.

This paper develops an in vitro marmoset brain model using cerebral assembloids to study neural development and activity.

The paper identifies enhanced endogenous Ca2+ signaling as a predictor of elimination in adult-born neurons in the mouse olfactory bulb.

This study shows that Derlin-1 maintains adult neurogenesis by regulating Stat5b, thereby affecting seizure susceptibility and cognitive function in mice.

This study identifies biallelic PNPLA8 variants causing microcephaly by reducing basal radial glia in cerebral organoids and disrupting phospholipid metabolism.

This study shows that loss of LRP1 in adult neural stem cells impairs their migration to ischemic lesions both in vivo and in vitro.

The paper examines immature neuron development in primate amygdala, finding maturation and reduced neuron counts with age, and no effect of maternal separation on immature neuron counts but a correlation with mature neuron counts.

The paper quantifies axon ensheathment dynamics in zebrafish oligodendrocytes, finding a high and consistent sheath destabilization rate despite variable initiation.