Herpesvirus Infections and Treatments

This study shows that CCL28 mobilizes HSV-specific memory B and T cells in vaginal mucosa, providing protection against genital herpes.

This study shows PRV hijacks DDX3X in sensory neurons to cause 'mad itch' and immune suppression, aiding viral spread.

This study shows that AAV-delivered gene editing reduces latent HSV DNA in mice and decreases viral shedding, with some toxicity observed at high doses.

The paper determines the crystal structures of EHV-1 and EHV-4 glycoprotein D (gD) and identifies key residues critical for binding to MHC-I, providing insights for antiviral drug and vaccine development.

This study infects human brain organoids with HSV-1 and identifies molecular and cellular changes associated with neurodegeneration.

The paper characterizes antiviral resistance in HSV-1 from a DOCK8-deficient patient using phenotypic and genotypic methods, finding genotypic testing more effective and documenting rapid intrahost HSV-1 evolution.

This study identifies interspecies recombination events in HSV-2 genomes and shows their impact on genetic variation and T-cell recognition.