Heavy Metal Exposure and Toxicity

This study examines how different levels of lead exposure affect neural differentiation in SH-SY5Y cells, showing significant changes in protein expression and cell morphology.

This study shows that Brideliaferruginea extract reduces cadmium chloride toxicity in rats by improving reproductive hormones, oxidative stress, liver and kidney damage, and hematological parameters.

The paper establishes a humanized neuronal model to investigate the effects of manganese dysregulation on neuronal function and disease mechanisms.

This study examines the toxic effects of lead nitrate on human keratinocytes, finding cytotoxicity, genotoxicity, oxidative stress, and mitochondrial dysfunction at varying concentrations.

This study shows DNA and RNA aptamers protect C. elegans and human cells from lead toxicity by mitigating reproductive, behavioral, and osteogenic effects.

This study shows cadmium exposure disrupts blood-testis barrier function in prepubertal rats via oxidative stress-induced autophagy and mTOR2 signaling impairment.

This study constructs the first adverse outcome pathway network for inorganic cadmium toxicity by integrating data from multiple sources and analyzing key events and relationships.

The paper identifies manganese deficiency and neurotoxicity in zebrafish slc39a14 mutants through transcriptome analysis, revealing key molecular pathways involved in manganese homeostasis disruption.

This study identifies circRNA, lncRNA, miRNA, and mRNA regulatory networks affected by cadmium exposure in C. elegans, revealing potential molecular mechanisms of Cd toxicity.

This study shows that SLC30A10 in dopaminergic neurons protects against manganese-induced neurotoxicity, while its absence in GABAergic neurons does not cause similar deficits.

This study shows that low-dose lead exposure alters heterochromatin marks in SH-SY5Y cells, with some changes persisting through differentiation and affecting neuronal morphology.

This study investigates the effects of chronic lead exposure on hippocampal network dynamics and behavior in rats, finding altered rhythms and impaired cognitive functions.

This study shows that deleting ZIP14 in the intestine causes manganese overload in the brain and motor defects, highlighting its role in manganese excretion.

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

This study identifies persistent transcriptional and epigenetic changes in human lung epithelial cells after nickel exposure, revealing mechanisms behind long-term health effects.

The paper identifies differentially expressed genes between welding fumes and five neurodegenerative diseases using network analysis and gene expression data.

The paper identifies genes involved in zinc detoxification in Drosophila cells through functional genomics and transcriptomics analyses, revealing key pathways and human disease-related gene orthologs.

This study shows that cadmium exposure disrupts otolith formation in zebrafish, leading to balance disorders and hyperactivity, with calcium rescue for otolith defects but not hyperactivity.